Literature summary for 3.1.1.79 extracted from

Takanashi, M.; Taira, Y.; Okazaki, S.; Takase, S.; Kimura, T.; Li, C.C.; Xu, P.F.; Noda, A.; Sakata, I.; Kumagai, H.; Ikeda, Y.; Iizuka, Y.; Yahagi, N.; Shimano, H.; Osuga, J.I.; Ishibashi, S.; Kadowaki, T.; Okazaki, H.
Role of hormone-sensitive lipase in leptin-promoted fat loss and glucose lowering (2017), J. Artheroscler. Thromb., 24, 110-1116 .

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Application

Application	Comment	Organism
medicine	hyperleptinemia equally suppresses the food intake in wild-type and Hsl KO mice. Leptin-mediated fat loss and glucose-lowering are significantly blunted in the absence of HSL when leptin is overexpressed by recombinant adenovirus carrying leptin. Hsl KO mice have a tendency to retain more fat than wild-type mice in the face of hyperleptinemia	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	P54310	-	-

General Information

General Information	Comment	Organism
physiological function	hyperleptinemia equally suppresses the food intake in wild-type and Hsl KO mice. Leptin-mediated fat loss and glucose-lowering are significantly blunted in the absence of HSL when leptin is overexpressed by recombinant adenovirus carrying leptin. Hsl KO mice have a tendency to retain more fat than wild-type mice in the face of hyperleptinemia	Mus musculus

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Release 2023.1 (January 2023)