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Literature summary for 3.1.1.79 extracted from

  • Kittilson, J.D.; Reindl, K.M.; Sheridan, M.A.
    Rainbow trout (Oncorhynchus mykiss) possess two hormone-sensitive lipase-encoding mRNAs that are differentially expressed and independently regulated by nutritional state (2011), Comp. Biochem. Physiol. A, 158, 52-60.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
isozyme HSL1, DNA and amino acid sequence determination and analysis, sequence comparison of HSL1 and HSL2, and phylogenetic analysis, quantitative real-time PCR expression analysis Oncorhynchus mykiss
isozyme HSL2, DNA and amino acid sequence determination and analysis, sequence comparison of HSL1 and HSL2, and phylogenetic analysis, quantitative real-time PCR expression analysis Oncorhynchus mykiss

Organism

Organism UniProt Comment Textmining
Oncorhynchus mykiss E2JFF5 HSL1; isozymes HSL1
-
Oncorhynchus mykiss E2JFF6 HSL2; isozyme HSL2
-

Synonyms

Synonyms Comment Organism
HSL1
-
Oncorhynchus mykiss
HSL2
-
Oncorhynchus mykiss

Expression

Organism Comment Expression
Oncorhynchus mykiss short term fasting over 4 weeks increases HSL1 and HSL2 mRNA expression in the adipose tissue, but only HSL1 mRNA levels increase in the liver and the red muscle. During a prolonged fast of 6 weeks, there is continued elevation of HSL1 and HSL2 mRNA levels in the liver and muscle, HSL mRNA expression in mesenteric fat declines, coincident with depletion of mesenteric fat mass. The upregulations are reversible up

General Information

General Information Comment Organism
evolution phylogentic analysis suggests that the two HSL isozymes derive from paralogous genes that may have arisen during a teleost-specific genome duplication event Oncorhynchus mykiss
additional information the organism possesses two hormone-sensitive lipase-encoding mRNAs that are differentially expressed and independently regulated by nutritional state Oncorhynchus mykiss