Cloned (Comment) | Organism |
---|---|
isozyme HSL1, DNA and amino acid sequence determination and analysis, sequence comparison of HSL1 and HSL2, and phylogenetic analysis, quantitative real-time PCR expression analysis | Oncorhynchus mykiss |
isozyme HSL2, DNA and amino acid sequence determination and analysis, sequence comparison of HSL1 and HSL2, and phylogenetic analysis, quantitative real-time PCR expression analysis | Oncorhynchus mykiss |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Oncorhynchus mykiss | E2JFF5 | HSL1; isozymes HSL1 | - |
Oncorhynchus mykiss | E2JFF6 | HSL2; isozyme HSL2 | - |
Synonyms | Comment | Organism |
---|---|---|
HSL1 | - |
Oncorhynchus mykiss |
HSL2 | - |
Oncorhynchus mykiss |
Organism | Comment | Expression |
---|---|---|
Oncorhynchus mykiss | short term fasting over 4 weeks increases HSL1 and HSL2 mRNA expression in the adipose tissue, but only HSL1 mRNA levels increase in the liver and the red muscle. During a prolonged fast of 6 weeks, there is continued elevation of HSL1 and HSL2 mRNA levels in the liver and muscle, HSL mRNA expression in mesenteric fat declines, coincident with depletion of mesenteric fat mass. The upregulations are reversible | up |
General Information | Comment | Organism |
---|---|---|
evolution | phylogentic analysis suggests that the two HSL isozymes derive from paralogous genes that may have arisen during a teleost-specific genome duplication event | Oncorhynchus mykiss |
additional information | the organism possesses two hormone-sensitive lipase-encoding mRNAs that are differentially expressed and independently regulated by nutritional state | Oncorhynchus mykiss |