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Literature summary for 3.1.1.79 extracted from
- In vitro stereoselective hydrolysis of diacylglycerols by hormone-sensitive lipase (2010), Biochim. Biophys. Acta, 1801, 77-83.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| human HSL is expressed from baculovirus-infected insect cells | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | the enzyme a substrate preference for the diacylglycerols originating from triacylglycerols. The ee% of 1,2-sn-diolein over 2,3-sn-diolein increases with the level of hydrolysis indicated that HSL has a preference for 2,3-sn-diolein as a substrate and therefore a stereopreference for the sn-3 position of dioleoylglycerol. The ee% of 1,2-sn-diolein reaches a maximum value of 36% at 42% hydrolysis | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| recombinant human HSL from baculovirus-infected insect cells | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| adipocyte | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | the enzyme a substrate preference for the diacylglycerols originating from triacylglycerols. The ee% of 1,2-sn-diolein over 2,3-sn-diolein increases with the level of hydrolysis indicated that HSL has a preference for 2,3-sn-diolein as a substrate and therefore a stereopreference for the sn-3 position of dioleoylglycerol. The ee% of 1,2-sn-diolein reaches a maximum value of 36% at 42% hydrolysis | Homo sapiens | ? | - |
? | |
| rac 1,2(2,3)-sn diolein + H2O | - |
Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| HSL | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8 | - |
assay at | Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | hormone-sensitive lipase contributes importantly to the mobilization of fatty acids in adipocytes and shows a substrate preference for the diacylglycerols originating from triacylglycerols | Homo sapiens |
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Release 2023.1 (January 2023)
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