Literature summary for 3.1.1.79 extracted from

Yonezawa, T.; Haga, S.; Kobayashi, Y.; Katoh, K.; Obara, Y.
Regulation of hormone-sensitive lipase expression by saturated fatty acids and hormones in bovine mammary epithelial cells (2008), Biochem. Biophys. Res. Commun., 376, 36-39.

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Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	stearate and palmitate, saturated fatty acids but not unsaturated fatty acids (oleate and linoleate) induce up-regulation of HSL mRNA in a time- and concentration-dependent manner in bMEC. Oleate and linoleate induce no up-regulation of HSL mRNA	Bos taurus

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	insulin (5-10 ng/ml) induces down-regulation of HSL, dexamethasone (50250 nM) induces down-regulation of HSL, bovine growth hormone (50 ng/ml) induces down-regulation of HSL	Bos taurus

Organism

Organism	UniProt	Comment	Textmining
Bos taurus	P16386	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
mammary epithelial cell	bMEC	Bos taurus	-
mammary gland	-	Bos taurus	-

Synonyms

Synonyms	Comment	Organism
hormone-sensitive lipase	-	Bos taurus
HSL	-	Bos taurus

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Release 2023.1 (January 2023)