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Literature summary for 3.1.1.79 extracted from

  • De Jong, J.C.; Sorensen, L.G.; Tornqvist, H.; Jacobsen, P.
    Carbazates as potent inhibitors of hormone-sensitive lipase (2004), Bioorg. Med. Chem. Lett., 14, 1741-1744.
    View publication on PubMed
Search for more literature for 3.1.1.79

Inhibitors

Inhibitors Comment Organism Structure
(3,4-dihydro-1H-isoquinolin-2-yl)-carbamic acid 4-tert-butoxycarbonylamino-phenyl ester IC50: 3 nM Homo sapiens
2-methoxyphenyl 3,4-dihydroisoquinolin-2(1H)-ylcarbamate IC50: 6400 nM Homo sapiens
4-(acetylamino)phenyl morpholin-4-ylcarbamate
-
 Homo sapiens
4-(butyrylamino)phenyl morpholin-4-ylcarbamate IC50: 3200 nM Homo sapiens
4-benzoylphenyl 3,4-dihydroisoquinolin-2(1H)-ylcarbamate
-
 Homo sapiens
4-benzylphenyl 3,4-dihydroisoquinolin-2(1H)-ylcarbamate IC50: 97 nM Homo sapiens
4-chlorophenyl (1-methyl-3,4-dihydroisoquinolin-2(1H)-yl)carbamate IC50: 32 nM Homo sapiens
4-chlorophenyl (3-methyl-3,4-dihydroisoquinolin-2(1H)-yl)carbamate IC50: 35 nM Homo sapiens
4-chlorophenyl 2,2-bis(2-ethoxyethyl)hydrazinecarboxylate IC50: 184 nM Homo sapiens
4-chlorophenyl 2,2-dipentylhydrazinecarboxylate IC50: 50 nM Homo sapiens
4-chlorophenyl 3,4-dihydroisoquinolin-2(1H)-ylcarbamate IC50: 19 nM Homo sapiens
4-methoxyphenyl 3,4-dihydroisoquinolin-2(1H)-ylcarbamate IC50: 360 nM Homo sapiens
4-[(2,2-dimethylpropanoyl)amino]phenyl morpholin-4-ylcarbamate IC50: 47 nM Homo sapiens
4-[(cyclohexylcarbonyl)amino]phenyl morpholin-4-ylcarbamate IC50: 10 nM Homo sapiens
benzyl (4-[[(morpholin-4-ylamino)carbonyl]oxy]phenyl)acetate IC50: 5 nM Homo sapiens
ethyl (4-[[(morpholin-4-ylamino)carbonyl]oxy]phenyl)acetate IC50: 138 nM Homo sapiens
methyl 4-[[(3,4-dihydroisoquinolin-2(1H)-ylamino)carbonyl]oxy]benzoate IC50: 9952 nM Homo sapiens
morpholin-4-yl-carbamic acid 4-[(4-tert-butyl-cyclohexanecarbonyl)-amino]-phenyl ester IC50: 1 nM Homo sapiens
N',N'-bis-(2-butylamino-ethyl)-hydrazinecarboxylic acid 4-chloro-phenyl ester IC50: 24 nM Homo sapiens
N',N'-bis-[2-(ethyl-methyl-amino)-ethyl]-hydrazinecarboxylic acid 4-chloro-phenyl ester IC50: 515 nM Homo sapiens
phenyl 3,4-dihydroisoquinolin-2(1H)-ylcarbamate IC50: 205 nM Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 recombinant
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
trioleoylglycerol + H2O
-
 Homo sapiens dioleoylglycerol + oleate
-
 ?

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000001
-
 IC50: 1 nM Homo sapiens morpholin-4-yl-carbamic acid 4-[(4-tert-butyl-cyclohexanecarbonyl)-amino]-phenyl ester
0.000003
-
 IC50: 3 nM Homo sapiens (3,4-dihydro-1H-isoquinolin-2-yl)-carbamic acid 4-tert-butoxycarbonylamino-phenyl ester
0.000005
-
 IC50: 5 nM Homo sapiens benzyl (4-[[(morpholin-4-ylamino)carbonyl]oxy]phenyl)acetate
0.00001
-
 IC50: 10 nM Homo sapiens 4-[(cyclohexylcarbonyl)amino]phenyl morpholin-4-ylcarbamate
0.000019
-
 IC50: 19 nM Homo sapiens 4-chlorophenyl 3,4-dihydroisoquinolin-2(1H)-ylcarbamate
0.000024
-
 IC50: 24 nM Homo sapiens N',N'-bis-(2-butylamino-ethyl)-hydrazinecarboxylic acid 4-chloro-phenyl ester
0.000032
-
 IC50: 32 nM Homo sapiens 4-chlorophenyl (1-methyl-3,4-dihydroisoquinolin-2(1H)-yl)carbamate
0.000035
-
 IC50: 35 nM Homo sapiens 4-chlorophenyl (3-methyl-3,4-dihydroisoquinolin-2(1H)-yl)carbamate
0.000047
-
 IC50: 47 nM Homo sapiens 4-[(2,2-dimethylpropanoyl)amino]phenyl morpholin-4-ylcarbamate
0.00005
-
 IC50: 50 nM Homo sapiens 4-chlorophenyl 2,2-dipentylhydrazinecarboxylate
0.000097
-
 IC50: 97 nM Homo sapiens 4-benzylphenyl 3,4-dihydroisoquinolin-2(1H)-ylcarbamate
0.000138
-
 IC50: 138 nM Homo sapiens ethyl (4-[[(morpholin-4-ylamino)carbonyl]oxy]phenyl)acetate
0.000184
-
 IC50: 184 nM Homo sapiens 4-chlorophenyl 2,2-bis(2-ethoxyethyl)hydrazinecarboxylate
0.000205
-
 IC50: 205 nM Homo sapiens phenyl 3,4-dihydroisoquinolin-2(1H)-ylcarbamate
0.00036
-
 IC50: 360 nM Homo sapiens 4-methoxyphenyl 3,4-dihydroisoquinolin-2(1H)-ylcarbamate
0.000515
-
 IC50: 515 nM Homo sapiens N',N'-bis-[2-(ethyl-methyl-amino)-ethyl]-hydrazinecarboxylic acid 4-chloro-phenyl ester
0.0032
-
 IC50: 3200 nM Homo sapiens 4-(butyrylamino)phenyl morpholin-4-ylcarbamate
0.0064
-
 IC50: 6400 nM Homo sapiens 2-methoxyphenyl 3,4-dihydroisoquinolin-2(1H)-ylcarbamate
0.009952
-
 IC50: 9952 nM Homo sapiens methyl 4-[[(3,4-dihydroisoquinolin-2(1H)-ylamino)carbonyl]oxy]benzoate