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Literature summary for 3.1.1.79 extracted from

  • Yeaman, S.J.
    Hormone-sensitive lipase - new roles for an old enzyme (2004), Biochem. J., 379, 11-22.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.1.79

Inhibitors

Inhibitors Comment Organism Structure
diisopropyl fluorophosphate serine hydrolase, active-site at position 424 Homo sapiens
diisopropyl fluorophosphate serine hydrolase with the active-site serine at position 423 Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
84000
-
 x * 84000, SDS-PAGE Rattus norvegicus
84032
-
 x * 84032, deduced from nucleotide sequence Homo sapiens
88000
-
 x * 88000, SDS-PAGE Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-
Rattus norvegicus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein
-
 Homo sapiens
phosphoprotein basal phosphorylation site at S565, regulatory phosphorylation site at S563, S659 and S660 may also be phosphorylated, HSL is probably also phosphorylated by extracellular-signal-regulated kinase Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
adipose tissue
-
 Mus musculus
-
macrophage
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
triacylglycerol + H2O
-
 Mus musculus diacylglycerol + a carboxylate
-
 ?
triacylglycerol + H2O
-
 Homo sapiens diacylglycerol + a carboxylate
-
 ?
triacylglycerol + H2O
-
 Rattus norvegicus diacylglycerol + a carboxylate
-
 ?

Subunits

Subunits Comment Organism
? x * 84000, SDS-PAGE Rattus norvegicus
? x * 88000, SDS-PAGE Homo sapiens
? x * 84032, deduced from nucleotide sequence Homo sapiens

Synonyms

Synonyms Comment Organism
HSL
-
 Mus musculus
HSL
-
 Homo sapiens
HSL
-
 Rattus norvegicus