Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
3-(acyloxy)acyl group of bacterial toxin + H2O | Mus musculus | host AOAH selectively removes the secondary fatty acyl chains from bacterial lipopolysaccharides, that are required for lipopolysaccharide recognition by its mammalian signaling receptor, MD-2-TLR4. Possibility that AOAH, by inactivating bacterial lipopolysaccharide within the liver and spleen, is an important endogenous control mechanism. Recombinant AOAH restores hepatic LPS deacylation and prevented LPS-induced hepatomegaly in Aoah-/- mice | 3-hydroxyacyl group of bacterial toxin + a fatty acid | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | O35298 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
Kupffer cell | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3-(acyloxy)acyl group of bacterial toxin + H2O | host AOAH selectively removes the secondary fatty acyl chains from bacterial lipopolysaccharides, that are required for lipopolysaccharide recognition by its mammalian signaling receptor, MD-2-TLR4. Possibility that AOAH, by inactivating bacterial lipopolysaccharide within the liver and spleen, is an important endogenous control mechanism. Recombinant AOAH restores hepatic LPS deacylation and prevented LPS-induced hepatomegaly in Aoah-/- mice | Mus musculus | 3-hydroxyacyl group of bacterial toxin + a fatty acid | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AOAH | - |
Mus musculus |