Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2,3-dimethylmaleic anhydride | biochemical efficacy, molecular docking and inhibitory effect on insect acetylcholinesterase. The knockdown activity of 2,3-dimethylmaleic anhydride is associated with in vivo inhibition of AChE, at KD99 dosage, it shows more than 90% inhibition of AChE activity in insects. 2,3-Dimethylmaleic anhydride elicits toxicity in Periplaneta americana primarily by AChE inhibition along with oxidative stress. The compound interacts with 9 amino acids forming hydrogen bonds with Cys198 and Glu199. Residues Glu191, and Phe202 are contributors of polar or electrostatic interaction, whereas the Phe241, Phe200, and Tyr244 are involved in van der Waals interactions | Periplaneta americana | |
2,3-dimethylmaleic anhydride | biochemical efficacy, molecular docking and inhibitory effect on insect acetylcholinesterase. The knockdown activity of 2,3-dimethylmaleic anhydride is associated with in vivo inhibition of AChE, at KD99 dosage, it shows more than 90% inhibition of AChE activity in insects. 2,3-Dimethylmaleic anhydride elicits toxicity in Sitophilus oryzae primarily by AChE inhibition along with oxidative stress | Sitophilus oryzae | |
pyridostigmine | - |
Periplaneta americana | |
pyridostigmine | - |
Sitophilus oryzae |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetylcholine + H2O | Sitophilus oryzae | - |
choline + acetate | - |
? | |
acetylcholine + H2O | Periplaneta americana | - |
choline + acetate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Periplaneta americana | A0A0P0DIY6 | collected from Insect Culture centre, at Department of Food Protectant and Infestation Control, CSIR-Central Food Technological Research Institute, Mysore, Karnataka, India | - |
Sitophilus oryzae | - |
collected at ware house of Food Corporation India, Imphal, Manipur, India | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
neural ganglion | - |
Periplaneta americana | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetylcholine + H2O | - |
Sitophilus oryzae | choline + acetate | - |
? | |
acetylcholine + H2O | - |
Periplaneta americana | choline + acetate | - |
? | |
acetylthiocholine + H2O | - |
Sitophilus oryzae | thiocholine + acetate | - |
? | |
acetylthiocholine + H2O | - |
Periplaneta americana | thiocholine + acetate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AChE | - |
Sitophilus oryzae |
AChE | - |
Periplaneta americana |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
25 | 37 | assay at | Sitophilus oryzae |
25 | 37 | assay at | Periplaneta americana |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | - |
assay at | Sitophilus oryzae |
8 | - |
assay at | Periplaneta americana |
General Information | Comment | Organism |
---|---|---|
additional information | substrate binding site, structure homology modelling, overview | Periplaneta americana |