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Literature summary for 3.1.1.7 extracted from
- Identification and molecular characterization of two acetylcholinesterases from the salmon louse, Lepeophtheirus salmonis (2015), PLoS ONE, 10, e0125362 .
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| gene ace1a, presence of two versions of ace1 gene named ace1a and ace1b, DNA and amino acid sequence determination and analysis, genomic organization, sequence comparisons and phylogenetic analysis and tree, quantitative enzyme expression analysis | Lepeophtheirus salmonis |
| gene ace1b, presence of two versions of ace1 gene named ace1a and ace1b, DNA and amino acid sequence determination and analysis, genomic organization, sequence comparisons and phylogenetic analysis and tree, quantitative enzyme expression analysis | Lepeophtheirus salmonis |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | resistance towards organophosphates is widespread in the marine arthropod Lepeophtheirus salmonis; resistance towards organophosphates is widespread in the marine arthropod Lepeophtheirus salmonis | Lepeophtheirus salmonis |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetylcholine + H2O | Lepeophtheirus salmonis | - |
choline + acetate | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Lepeophtheirus salmonis | A0A0A7E972 | fish and the parasites originated from the western part of the county Finnmark in northern Norway | - |
| Lepeophtheirus salmonis | A0A0A7E9D3 | fish and the parasites originated from the western part of the county Finnmark in northern Norway | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| cephalothorax | isozyme Ace1a is possibly active in the cephalothorax, significant staining for ace1a in the central ganglion and in the posterior part of the intestinal wall in the cephalothorax segment | Lepeophtheirus salmonis | - |
| intestinal wall | - |
Lepeophtheirus salmonis | - |
| additional information | isozyme Ace1a is predominantly expressed in different developmental stages compared to isozyme Ace1b. The relative expression level of ace1a is significantly higher than ace1b, especially at the copepodid (26fold) stage followed by preadult females (13fold). The significantly higher transcription level of ace1a suggests that it is the predominantly expressed gene in Lepeophtheirus salmonis | Lepeophtheirus salmonis | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetylcholine + H2O | - |
Lepeophtheirus salmonis | choline + acetate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| More | three-dimensional structure modelling of Lepeophtheirus salmonis AChE variants, overview | Lepeophtheirus salmonis |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ace1a | - |
Lepeophtheirus salmonis |
| ace1b | - |
Lepeophtheirus salmonis |
| AChE | - |
Lepeophtheirus salmonis |
| AChE1A | - |
Lepeophtheirus salmonis |
General Information
| General Information | Comment | Organism |
|---|---|---|
| additional information | three-dimensional structure modelling of Lepeophtheirus salmonis AChE variants, overview | Lepeophtheirus salmonis |
| physiological function | isozyme Ace1a is possibly active in the cephalothorax, indicating that isozyme Ace1a is likely to play the major role in cholinergic synaptic transmission. Isozyme AChE1a plays an important role in terminating ACh-generated signals at the postsynaptic level | Lepeophtheirus salmonis |
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