Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-oxo-N-[2-(piperidin-1-yl)ethyl]-2H-chromene-3-carboxamide | - |
Electrophorus electricus | |
7-hydroxy-3-(piperidin-1-ylcarbonyl)-2H-chromen-2-one | - |
Electrophorus electricus | |
ethyl 2-oxo-7-[2-(piperidin-1-yl)ethoxy]-2H-chromene-3-carboxylate | - |
Electrophorus electricus | |
ethyl 7-hydroxy-8-(3-methoxyphenyl)-2-oxo-2H-chromene-3-carboxylate | - |
Electrophorus electricus | |
additional information | designed and molecular recognition studies of coumarin-based inhibitors towards acetylcholinesterase (AChE), molecular docking simulations, dissociation constant and bound conformations of these inhibitors within the inhibitor-AChE complex, overview. The docking simulations mimic NMR results | Electrophorus electricus | |
tacrine | - |
Electrophorus electricus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetylcholine + H2O | Electrophorus electricus | - |
choline + acetate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Electrophorus electricus | O42275 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
commercial preparation | - |
Electrophorus electricus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetylcholine + H2O | - |
Electrophorus electricus | choline + acetate | - |
? | |
acetylthiocholine + H2O | - |
Electrophorus electricus | thiocholine + acetate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AChE | - |
Electrophorus electricus |
General Information | Comment | Organism |
---|---|---|
physiological function | the enzyme acetylcholinesterase (AChE) exists mainly in the synaptic clefts (between nerves and skeletal muscle) and the central nervous system (CNS) of living organisms, and is mostly responsible for proper muscle functioning as well as signal transmissions. AChE hydrolyzes ACh into choline and acetate ion at synapses with a very fast functioning rate, resulting in the loss of stimulatory activity | Electrophorus electricus |