Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(2,3-trans)-3-(3-hydroxy-5-methoxyphenyl)-N-(4-hydroxyphenethyl)-7-((E)-3-[(4-hydroxyphenethyl)amino]-3-oxoprop-1-enyl)-2,3-dihydro-benzo[b][1,4]dioxine-2-carboxamide | - |
Tetronarce californica | |
3,3'-demethyl-grossamide | 87.37% inhibition at 0.1 mg/ml | Tetronarce californica | |
3,3'-demethyl-heliotropamide | 62.84% inhibition at 0.1 mg/ml | Tetronarce californica | |
cannabisin A | 47.13% inhibition at 0.1 mg/ml | Tetronarce californica | |
cannabisin C | 42.89% inhibition at 0.1 mg/ml | Tetronarce californica | |
cannabisin D | 13.97% inhibition at 0.1 mg/ml | Tetronarce californica | |
cannabisin E | 11.17% inhibition at 0.1 mg/ml | Tetronarce californica | |
cannabisin F | 47.16% inhibition at 0.1 mg/ml | Tetronarce californica | |
cannabisin M | - |
Tetronarce californica | |
cannabisin N | 51.99% inhibition at 0.1 mg/ml | Tetronarce californica | |
cannabisin O | - |
Tetronarce californica | |
galantamine | 89.26% inhibition at 0.1 mg/ml, docking study using the enzyme's crystal structure, PBD ID 1DX6 | Tetronarce californica | |
grossamide | 22.42% inhibition at 0.1 mg/ml | Tetronarce californica | |
additional information | acetylcholinesterase inhibitory activities of lignanamides from hemp, Cannabis sativa, seeds, NMR compound structure analysis and structure comparisons, molecular modeling studies on AChE, overview | Tetronarce californica | |
N-trans-caffeoyltyramine | 83.28% inhibition at 0.1 mg/ml | Tetronarce californica | |
N-trans-feruloyltyramine | 13.25% inhibition at 0.1 mg/ml | Tetronarce californica |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetylcholine + H2O | Tetronarce californica | - |
choline + acetate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Tetronarce californica | P04058 | i.e. Tetronarce californica | - |
Source Tissue | Comment | Organism | Textmining |
---|
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetylcholine + H2O | - |
Tetronarce californica | choline + acetate | - |
? | |
acetylthiocholine + H2O | - |
Tetronarce californica | thiocholine + acetate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AChE | - |
Tetronarce californica |
TcAChE | - |
Tetronarce californica |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Tetronarce californica |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.8 | - |
assay at | Tetronarce californica |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00276 | - |
pH 7.8, 25°C | Tetronarce californica | galantamine | |
0.0387 | - |
pH 7.8, 25°C | Tetronarce californica | 3,3'-demethyl-grossamide | |
0.0462 | - |
pH 7.8, 25°C | Tetronarce californica | 3,3'-demethyl-heliotropamide | |
0.216 | - |
pH 7.8, 25°C | Tetronarce californica | N-trans-caffeoyltyramine |