Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.1.1.7 extracted from

  • Larik, F.A.; Shah, M.S.; Saeed, A.; Shah, H.S.; Channar, P.A.; Bolte, M.; Iqbal, J.
    New cholinesterase inhibitors for Alzheimers disease structure activity relationship, kinetics and molecular docking studies of 1-butanoyl-3-arylthiourea derivatives (2018), Int. J. Biol. Macromol., 116, 144-150 .
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
1-butanoyl-3-(2,6-dimethylphenyl)thiourea
-
Homo sapiens
1-butanoyl-3-(3-methoxyphenyl)thiourea
-
Homo sapiens
1-butanoyl-3-(4-chlorophenyl)thiourea
-
Homo sapiens
1-butanoyl-3-benzylthiourea
-
Homo sapiens
additional information structure-activity relationships, kinetics and molecular docking studies of 1-butanoyl-3-arylthiourea derivatives, overview Homo sapiens
N-(1,3-thiazol-5-ylcarbamothioyl)butanamide
-
Homo sapiens
N-[(2,3-dichlorophenyl)carbamothioyl]butanamide
-
Homo sapiens
N-[(2,4,6-trimethylphenyl)carbamothioyl]butanamide
-
Homo sapiens
N-[(2,4-dichlorophenyl)carbamothioyl]butanamide
-
Homo sapiens
N-[(2,6-dichloro-4-fluorophenyl)carbamothioyl]butanamide
-
Homo sapiens
N-[(2-methoxyphenyl)carbamothioyl]butanamide
-
Homo sapiens
N-[(3-nitrophenyl)carbamothioyl]butanamide
-
Homo sapiens
N-[(4-methoxyphenyl)carbamothioyl]butanamide
-
Homo sapiens
N-[(4-methylphenyl)carbamothioyl]butanamide
-
Homo sapiens
N-[(4-nitrophenyl)carbamothioyl]butanamide
-
Homo sapiens
neostigmine
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetylcholine + H2O Homo sapiens
-
choline + acetate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens P22303
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetylcholine + H2O
-
Homo sapiens choline + acetate
-
?

Synonyms

Synonyms Comment Organism
AChE
-
Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00892
-
pH 7.7, 37°C Homo sapiens 1-butanoyl-3-(2,6-dimethylphenyl)thiourea
0.0104
-
pH 7.7, 37°C Homo sapiens N-(1,3-thiazol-5-ylcarbamothioyl)butanamide
0.0117
-
pH 7.7, 37°C Homo sapiens 1-butanoyl-3-(4-chlorophenyl)thiourea
0.0222
-
pH 7.7, 37°C Homo sapiens neostigmine
0.0264
-
pH 7.7, 37°C Homo sapiens N-[(3-nitrophenyl)carbamothioyl]butanamide
0.0297
-
pH 7.7, 37°C Homo sapiens N-[(4-nitrophenyl)carbamothioyl]butanamide
0.0343
-
pH 7.7, 37°C Homo sapiens 1-butanoyl-3-(3-methoxyphenyl)thiourea
0.0403
-
pH 7.7, 37°C Homo sapiens N-[(2,6-dichloro-4-fluorophenyl)carbamothioyl]butanamide
0.0425
-
pH 7.7, 37°C Homo sapiens N-[(4-methylphenyl)carbamothioyl]butanamide
0.0427
-
pH 7.7, 37°C Homo sapiens N-[(2,4-dichlorophenyl)carbamothioyl]butanamide
0.0491
-
pH 7.7, 37°C Homo sapiens N-[(4-methoxyphenyl)carbamothioyl]butanamide
0.0589
-
pH 7.7, 37°C Homo sapiens N-[(2,4,6-trimethylphenyl)carbamothioyl]butanamide
0.0966
-
pH 7.7, 37°C Homo sapiens N-[(2-methoxyphenyl)carbamothioyl]butanamide
0.1325
-
pH 7.7, 37°C Homo sapiens 1-butanoyl-3-benzylthiourea
0.158
-
pH 7.7, 37°C Homo sapiens N-[(2,3-dichlorophenyl)carbamothioyl]butanamide