Application | Comment | Organism |
---|---|---|
analysis | the enzyme immobilized on porous silicon can be exploited as a reusable biocatalyst and for screening of acetylcholinesterase inhibitors from crude plant extracts and synthesized organic compounds | Homo sapiens |
synthesis | the enzyme immobilized on porous silicon offers a possibilities as a viable biocatalyst in bioprocessing for the chemical and pharmaceutical industries, and bioremediation to enhance productivity and robustness | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | acetylcholinesterase is physically adsorbed on to a mesoporous silicon surface, immobilization method, overview. The porous silicon-immobilized enzyme retains 50% of its activity, shows thermal stability up to 90°C, reusability for up to three cycles, pH stability over a broad range of pH 4.0-9.0, and a shelf-life of 44 days, with an optimal hydrolytic response towards acetylthiocholine iodide at variable drug concentrations | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
neostigmine methyl sulfate | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetylcholine + H2O | Homo sapiens | - |
choline + acetate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P22303 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
erythrocyte | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetylcholine + H2O | - |
Homo sapiens | choline + acetate | - |
? | |
acetylthiocholine + H2O | substrate is acetylthiocholine iodide, activity detection using 5,5'-dithio-bis(2-nitrobenzoic acid) colorimetric assay and measurement of the absorbance at 412 nm | Homo sapiens | thiocholine + acetate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
acetylcholine hydrolase | - |
Homo sapiens |
AChE | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | - |
assay at | Homo sapiens |