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Literature summary for 3.1.1.7 extracted from
- 1-Naphthyl acetate a chromogenic substrate for the detection of erythrocyte acetylcholinesterase activity (2018), Biochimie, 154, 194-209 .
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| BW284c51 | specific inhibitor of AChE | Homo sapiens |  |
| dichlorvos | - |
Homo sapiens | |
| malaoxon | - |
Homo sapiens | |
| neostigmine | as bromide or metasulfate, a non-specific cholinesterase inhibitor, used to inhibit hemolysate AChE activity in order to understand the specificity of 1-naphthyl acetate or acetylthiocholine for AChE | Homo sapiens | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | kinetics | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetylcholine + H2O | Homo sapiens | - |
choline + acetate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| erythrocyte | - |
Homo sapiens | - |
| hemolysate | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 1-naphthyl acetate + H2O | a chromogenic substrate for detection of erythrocyte acetylcholinesterase activity | Homo sapiens | 1-naphthol + acetate | - |
? | |
| acetylcholine + H2O | - |
Homo sapiens | choline + acetate | - |
? | |
| acetylthiocholine + H2O | - |
Homo sapiens | thiocholine + acetate | - |
? | |
| additional information | nonspecific inhibitor neostigmine is used to inhibit hemolysate AChE activity in order to understand the specificity of AChE for 1-naphthyl acetate or acetylthiocholine, substrate docking with AChE, BChE (EC 3.1.1.8), albumin and esterase D, acetylcholine docks with AChE, BChE, albumin and esterase D, overview | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| AChE | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 22 | - |
assay at room temperature | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
assay at | Homo sapiens |
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Release 2023.1 (January 2023)
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