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Literature summary for 3.1.1.7 extracted from

  • Araujo, M.C.; Assis, C.R.; Silva, L.C.; Machado, D.C.; Silva, K.C.; Lima, A.V.; Carvalho, L.B.; Bezerra, R.de S.; Oliveira, M.B.
    Brain acetylcholinesterase of jaguar cichlid (Parachromis managuensis) from physicochemical and kinetic properties to its potential as biomarker of pesticides and metal ions (2016), Aquat. Toxicol., 177, 182-189 .
    View publication on PubMed

Application

Application Comment Organism
diagnostics the enzyme has potential as biomarker of pesticides and metal ions Parachromis managuensis

Inhibitors

Inhibitors Comment Organism Structure
BW284c51
-
Parachromis managuensis
Carbaryl
-
Parachromis managuensis
carbofuran
-
Parachromis managuensis
Cd2+ 25% inhibition at 1 mM Parachromis managuensis
Cu2+ 53% inhibition at 1 mM Parachromis managuensis
dichlorvos
-
Parachromis managuensis
eserine
-
Parachromis managuensis
Hg2+ complete inhibition at 1 mM Parachromis managuensis
iso-ompa
-
Parachromis managuensis
Mn2+ about 20% inhibition at 1 mM Parachromis managuensis
neostigmine
-
Parachromis managuensis
Pb2+ slight inhibition Parachromis managuensis
Zn2+ 17% inhibition at 1 mM Parachromis managuensis

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information Michaelis-Menten kinetics Parachromis managuensis
0.59
-
acetylthiocholine pH 8.0, 25°C Parachromis managuensis

Metals/Ions

Metals/Ions Comment Organism Structure
additional information no or poor effect by Al3+, Ba2+, Mg2+, Mn2+, and Fe2+ at 1 mM Parachromis managuensis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetylcholine + H2O Parachromis managuensis
-
choline + acetate
-
?

Organism

Organism UniProt Comment Textmining
Parachromis managuensis
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Parachromis managuensis
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetylcholine + H2O
-
Parachromis managuensis choline + acetate
-
?
acetylthiocholine + H2O
-
Parachromis managuensis thiocholine + acetate
-
?

Synonyms

Synonyms Comment Organism
AChE
-
Parachromis managuensis

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
35
-
-
Parachromis managuensis

Temperature Range [°C]

Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
20 40 over 60% of maximal activity within this range Parachromis managuensis

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
-
Parachromis managuensis

pH Range

pH Minimum pH Maximum Comment Organism
7 9 over 60% of maximal activity within this range Parachromis managuensis

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00012
-
Hg2+ pH 8.0, 25°C Parachromis managuensis
0.0012
-
eserine pH 8.0, 25°C Parachromis managuensis
0.0014
-
iso-ompa pH 8.0, 25°C Parachromis managuensis
0.0044
-
neostigmine pH 8.0, 25°C Parachromis managuensis
0.00725
-
Cu2+ pH 8.0, 25°C Parachromis managuensis
0.0082
-
BW284c51 pH 8.0, 25°C Parachromis managuensis
0.0343
-
Cd2+ pH 8.0, 25°C Parachromis managuensis
0.1216
-
Zn2+ pH 8.0, 25°C Parachromis managuensis

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.013
-
pH 8.0, 25°C Parachromis managuensis Hg2+
0.1165
-
pH 8.0, 25°C Parachromis managuensis Zn2+
0.17
-
pH 8.0, 25°C Parachromis managuensis eserine
0.2
-
pH 8.0, 25°C Parachromis managuensis iso-ompa
0.61
-
pH 8.0, 25°C Parachromis managuensis neostigmine
0.773
-
pH 8.0, 25°C Parachromis managuensis Cu2+
0.87
-
pH 8.0, 25°C Parachromis managuensis BW284c51
3.656
-
pH 8.0, 25°C Parachromis managuensis Cd2+
7.75
-
pH 8.0, 25°C Parachromis managuensis Pb2+
12.969
-
pH 8.0, 25°C Parachromis managuensis Zn2+