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Literature summary for 3.1.1.7 extracted from

  • Worek, F.; Bierwisch, A.; Wille, T.; Koller, M.; Thiermann, H.
    Kinetic interactions of a homologous series of bispyridinium monooximes (HGG oximes) with native and phosphonylated human acetylcholinesterase (2012), Toxicol. Lett., 212, 29-32.
    View publication on PubMed
Search for more literature for 3.1.1.7

Inhibitors

Inhibitors Comment Organism Structure
1-[[(3-acetylpyridinium-1-yl)methoxy]methyl]-2-[(E)-(hydroxyimino)methyl]pyridinium diiodide
-
 Homo sapiens
1-[[(3-butanoylpyridinium-1-yl)methoxy]methyl]-2-[(E)-(hydroxyimino)methyl]pyridinium diiodide
-
 Homo sapiens
1-[[(3-decanoylpyridinium-1-yl)methoxy]methyl]-2-[(E)-(hydroxyimino)methyl]pyridinium diiodide
-
 Homo sapiens
1-[[(3-heptanoylpyridinium-1-yl)methoxy]methyl]-2-[(E)-(hydroxyimino)methyl]pyridinium diiodide
-
 Homo sapiens
1-[[(3-hexanoylpyridinium-1-yl)methoxy]methyl]-2-[(E)-(hydroxyimino)methyl]pyridinium diiodide
-
 Homo sapiens
2-[(E)-(hydroxyimino)methyl]-1-[[(3-nonanoylpyridinium-1-yl)methoxy]methyl]pyridinium diiodide
-
 Homo sapiens
2-[(E)-(hydroxyimino)methyl]-1-[[(3-octanoylpyridinium-1-yl)methoxy]methyl]pyridinium diiodide
-
 Homo sapiens
2-[(E)-(hydroxyimino)methyl]-1-[[(3-pentanoylpyridinium-1-yl)methoxy]methyl]pyridinium diiodide
-
 Homo sapiens
2-[(E)-(hydroxyimino)methyl]-1-[[(3-propanoylpyridinium-1-yl)methoxy]methyl]pyridinium diiodide
-
 Homo sapiens
2-[(E)-(hydroxyimino)methyl]-1-[[(3-undecanoylpyridinium-1-yl)methoxy]methyl]pyridinium diiodide
-
 Homo sapiens
cyclosarin
-
 Homo sapiens
HI-6 more than 95% inhibition at 20 nM Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetylcholine + H2O Homo sapiens
-
 choline + acetate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
erythrocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetylcholine + H2O
-
 Homo sapiens choline + acetate
-
 ?
acetylthiocholine + H2O
-
 Homo sapiens thiocholine + acetate
-
 ?

Synonyms

Synonyms Comment Organism
AChE
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0087
-
 at pH 7.4 and 37°C Homo sapiens 1-[[(3-decanoylpyridinium-1-yl)methoxy]methyl]-2-[(E)-(hydroxyimino)methyl]pyridinium diiodide
0.0124
-
 at pH 7.4 and 37°C Homo sapiens 2-[(E)-(hydroxyimino)methyl]-1-[[(3-undecanoylpyridinium-1-yl)methoxy]methyl]pyridinium diiodide
0.0174
-
 at pH 7.4 and 37°C Homo sapiens 2-[(E)-(hydroxyimino)methyl]-1-[[(3-nonanoylpyridinium-1-yl)methoxy]methyl]pyridinium diiodide
0.0275
-
 at pH 7.4 and 37°C Homo sapiens 2-[(E)-(hydroxyimino)methyl]-1-[[(3-octanoylpyridinium-1-yl)methoxy]methyl]pyridinium diiodide
0.0555
-
 at pH 7.4 and 37°C Homo sapiens 1-[[(3-heptanoylpyridinium-1-yl)methoxy]methyl]-2-[(E)-(hydroxyimino)methyl]pyridinium diiodide
0.0828
-
 at pH 7.4 and 37°C Homo sapiens 1-[[(3-hexanoylpyridinium-1-yl)methoxy]methyl]-2-[(E)-(hydroxyimino)methyl]pyridinium diiodide
0.1486
-
 at pH 7.4 and 37°C Homo sapiens 2-[(E)-(hydroxyimino)methyl]-1-[[(3-pentanoylpyridinium-1-yl)methoxy]methyl]pyridinium diiodide
0.1649
-
 at pH 7.4 and 37°C Homo sapiens 1-[[(3-butanoylpyridinium-1-yl)methoxy]methyl]-2-[(E)-(hydroxyimino)methyl]pyridinium diiodide
0.2206
-
 at pH 7.4 and 37°C Homo sapiens 1-[[(3-acetylpyridinium-1-yl)methoxy]methyl]-2-[(E)-(hydroxyimino)methyl]pyridinium diiodide
0.2406
-
 at pH 7.4 and 37°C Homo sapiens 2-[(E)-(hydroxyimino)methyl]-1-[[(3-propanoylpyridinium-1-yl)methoxy]methyl]pyridinium diiodide