Literature summary for 3.1.1.7 extracted from

Acharya, J.; Dubey, D.K.; Srivastava, A.K.; Raza, S.K.
In vitro reactivation of sarin-inhibited human acetylcholinesterase (AChE) by bis-pyridinium oximes connected by xylene linkers (2011), Toxicol. In Vitro, 25, 251-256.

Search for more literature for 3.1.1.7

Activating Compound

Activating Compound	Comment	Organism	Structure
2-PAM	34% reactivation of enzyme inhibited by sarin at 1 mM within 10 min	Homo sapiens
N,N'-4-xylene-bis-[(2,2'-hydroxyiminomethyl)pyridinium] dibromide	most potent reactivator for enzyme inhibited by sarin (45% regeneration at 1 mM within 10 min)	Homo sapiens
N,N'-4-xylene-bis[(3,3'-hydroxyiminomethyl)-pyridinium] dibromide	33% reactivation of enzyme inhibited by sarin at 1 mM within 10 min	Homo sapiens
obidoxime	24% reactivation of enzyme inhibited by sarin at 1 mM within 10 min	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
sarin	-	Homo sapiens
soman	-	Homo sapiens
Tabun	-	Homo sapiens
VX	-	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
acetylcholine + H2O	Homo sapiens	-	choline + acetate	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
acetylcholine + H2O	-	Homo sapiens	choline + acetate	-	?
acetylthiocholine + H2O	-	Homo sapiens	thiocholine + acetate	-	?

Synonyms

Synonyms	Comment	Organism
AChE	-	Homo sapiens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)