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Literature summary for 3.1.1.7 extracted from

  • Akrami, H.; Mirjalili, B.F.; Khoobi, M.; Nadri, H.; Moradi, A.; Sakhteman, A.; Emami, S.; Foroumadi, A.; Shafiee, A.
    Indolinone-based acetylcholinesterase inhibitors: Synthesis, biological activity and molecular modeling (2014), Eur. J. Med. Chem., 84, 375-381.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
(E)-1-(2,4-dichlorobenzyl)-4-((2-oxoindolin-3-ylidene)methyl)pyridinium chloride
-
Electrophorus electricus
(E)-1-(2,6-dichlorobenzyl)-4-((2-oxoindolin-3-ylidene)methyl)pyridinium chloride
-
Electrophorus electricus
(E)-1-(2-bromobenzyl)-4-((2-oxoindolin-3-ylidene)methyl)pyridinium chloride
-
Electrophorus electricus
(E)-1-(2-chloro-6-fluorobenzyl)-4-((2-oxoindolin-3-ylidene)methyl)pyridinium chloride
-
Electrophorus electricus
(E)-1-(2-chlorobenzyl)-4-((2-oxoindolin-3-ylidene)methyl)pyridinium chloride
-
Electrophorus electricus
(E)-1-(2-fluorobenzyl)-4-((2-oxoindolin-3-ylidene)methyl)pyridinium chloride
-
Electrophorus electricus
(E)-1-(2-methylbenzyl)-4-((2-oxoindolin-3-ylidene)methyl)pyridinium chloride
-
Electrophorus electricus
(E)-1-(2-nitrobenzyl)-4-((2-oxoindolin-3-ylidene)methyl)pyridinium bromide
-
Electrophorus electricus
(E)-1-(3,4-dichlorobenzyl)-4-((2-oxoindolin-3-ylidene)methyl)pyridinium chloride
-
Electrophorus electricus
(E)-1-(3-bromobenzyl)-4-((2-oxoindolin-3-ylidene)methyl)pyridinium chloride
-
Electrophorus electricus
(E)-1-(3-chlorobenzyl)-4-((2-oxoindolin-3-ylidene)methyl)pyridinium bromide
-
Electrophorus electricus
(E)-1-(3-fluorobenzyl)-4-((2-oxoindolin-3-ylidene)methyl)pyridinium chloride
-
Electrophorus electricus
(E)-1-(3-methoxylbenzyl)-4-((2-oxoindolin-3-ylidene)methyl)pyridinium chloride
-
Electrophorus electricus
(E)-1-(3-methylbenzyl)-4-((2-oxoindolin-3-ylidene)methyl)pyridinium chloride
-
Electrophorus electricus
(E)-1-(4-bromobenzyl)-4-((2-oxoindolin-3-ylidene)methyl)pyridinium chloride
-
Electrophorus electricus
(E)-1-(4-chlorobenzyl)-4-((2-oxoindolin-3-ylidene)methyl)pyridinium chloride
-
Electrophorus electricus
(E)-1-(4-chloromethylbenzyl)-4-((2-oxoindolin-3-ylidene)methyl)pyridinium chloride
-
Electrophorus electricus
(E)-1-(4-fluorobenzyl)-4-((2-oxoindolin-3-ylidene)methyl)pyridinium chloride
-
Electrophorus electricus
(E)-1-(4-methoxybenzyl)-4-((2-oxoindolin-3-ylidene)methyl)pyridinium chloride
-
Electrophorus electricus
(E)-1-(4-nitrobenzyl)-4-((2-oxoindolin-3-ylidene)methyl)pyridinium chloride
-
Electrophorus electricus
(E)-1-(benzyl)-4-((2-oxoindolin-3-ylidene)methyl)pyridinium bromide
-
Electrophorus electricus
donepezil
-
Electrophorus electricus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetylcholine + H2O Electrophorus electricus
-
choline + acetate
-
?

Organism

Organism UniProt Comment Textmining
Electrophorus electricus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetylcholine + H2O
-
Electrophorus electricus choline + acetate
-
?
acetylthiocholine + H2O
-
Electrophorus electricus thiocholine + acetate
-
?

Synonyms

Synonyms Comment Organism
AChE
-
Electrophorus electricus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00000044
-
at pH 8.0 and 25°C Electrophorus electricus (E)-1-(2-chlorobenzyl)-4-((2-oxoindolin-3-ylidene)methyl)pyridinium chloride
0.00000125
-
at pH 8.0 and 25°C Electrophorus electricus (E)-1-(2-fluorobenzyl)-4-((2-oxoindolin-3-ylidene)methyl)pyridinium chloride
0.00000146
-
at pH 8.0 and 25°C Electrophorus electricus (E)-1-(2-bromobenzyl)-4-((2-oxoindolin-3-ylidene)methyl)pyridinium chloride
0.0000041
-
at pH 8.0 and 25°C Electrophorus electricus (E)-1-(2-chloro-6-fluorobenzyl)-4-((2-oxoindolin-3-ylidene)methyl)pyridinium chloride
0.0000049
-
at pH 8.0 and 25°C Electrophorus electricus (E)-1-(3-chlorobenzyl)-4-((2-oxoindolin-3-ylidene)methyl)pyridinium bromide
0.0000052
-
at pH 8.0 and 25°C Electrophorus electricus (E)-1-(3-methylbenzyl)-4-((2-oxoindolin-3-ylidene)methyl)pyridinium chloride
0.0000066
-
at pH 8.0 and 25°C Electrophorus electricus (E)-1-(3-methoxylbenzyl)-4-((2-oxoindolin-3-ylidene)methyl)pyridinium chloride
0.0000103
-
at pH 8.0 and 25°C Electrophorus electricus (E)-1-(3-bromobenzyl)-4-((2-oxoindolin-3-ylidene)methyl)pyridinium chloride
0.0000128
-
at pH 8.0 and 25°C Electrophorus electricus (E)-1-(3-fluorobenzyl)-4-((2-oxoindolin-3-ylidene)methyl)pyridinium chloride
0.000014
-
at pH 8.0 and 25°C Electrophorus electricus donepezil
0.0000153
-
at pH 8.0 and 25°C Electrophorus electricus (E)-1-(2-methylbenzyl)-4-((2-oxoindolin-3-ylidene)methyl)pyridinium chloride
0.000017
-
at pH 8.0 and 25°C Electrophorus electricus (E)-1-(2,6-dichlorobenzyl)-4-((2-oxoindolin-3-ylidene)methyl)pyridinium chloride
0.0000294
-
at pH 8.0 and 25°C Electrophorus electricus (E)-1-(3,4-dichlorobenzyl)-4-((2-oxoindolin-3-ylidene)methyl)pyridinium chloride
0.0000471
-
at pH 8.0 and 25°C Electrophorus electricus (E)-1-(benzyl)-4-((2-oxoindolin-3-ylidene)methyl)pyridinium bromide
0.0001034
-
at pH 8.0 and 25°C Electrophorus electricus (E)-1-(4-chloromethylbenzyl)-4-((2-oxoindolin-3-ylidene)methyl)pyridinium chloride
0.000214
-
at pH 8.0 and 25°C Electrophorus electricus (E)-1-(2-nitrobenzyl)-4-((2-oxoindolin-3-ylidene)methyl)pyridinium bromide
0.0002576
-
at pH 8.0 and 25°C Electrophorus electricus (E)-1-(2,4-dichlorobenzyl)-4-((2-oxoindolin-3-ylidene)methyl)pyridinium chloride
0.00059
-
at pH 8.0 and 25°C Electrophorus electricus (E)-1-(4-chlorobenzyl)-4-((2-oxoindolin-3-ylidene)methyl)pyridinium chloride
0.0006534
-
at pH 8.0 and 25°C Electrophorus electricus (E)-1-(4-bromobenzyl)-4-((2-oxoindolin-3-ylidene)methyl)pyridinium chloride
0.000677
-
at pH 8.0 and 25°C Electrophorus electricus (E)-1-(4-fluorobenzyl)-4-((2-oxoindolin-3-ylidene)methyl)pyridinium chloride
0.000677
-
at pH 8.0 and 25°C Electrophorus electricus (E)-1-(4-methoxybenzyl)-4-((2-oxoindolin-3-ylidene)methyl)pyridinium chloride
0.000744
-
at pH 8.0 and 25°C Electrophorus electricus (E)-1-(4-nitrobenzyl)-4-((2-oxoindolin-3-ylidene)methyl)pyridinium chloride