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Literature summary for 3.1.1.7 extracted from

  • Hung, T.M.; Dang, N.H.; Kim, J.C.; Jang, H.S.; Ryoo, S.W.; Lee, J.H.; Choi, J.S.; Bae, K.; Min, B.S.
    Alkaloids from roots of Stephania rotunda and their cholinesterase inhibitory activity (2010), Planta Med., 76, 1762-1764.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
7,8-dihydro-[1,3]dioxolo[4,5-g]isoquinoline
-
Rattus norvegicus
isocorydine
-
Rattus norvegicus
oxoxylopine
-
Rattus norvegicus
palmatine
-
Rattus norvegicus
remerine
-
Rattus norvegicus
stepharotudine
-
Rattus norvegicus
tacrine
-
Rattus norvegicus
tetrahydropalmatine
-
Rattus norvegicus
thalifoline
-
Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain cortex
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetylthiocholine + H2O
-
Rattus norvegicus thiocholine + acetate
-
?

Synonyms

Synonyms Comment Organism
AChE
-
Rattus norvegicus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00017
-
pH and temperature not specified in the publication Rattus norvegicus tacrine
0.0104
-
pH and temperature not specified in the publication Rattus norvegicus palmatine
0.0184
-
pH and temperature not specified in the publication Rattus norvegicus 7,8-dihydro-[1,3]dioxolo[4,5-g]isoquinoline
0.0207
-
pH and temperature not specified in the publication Rattus norvegicus remerine
0.038
-
pH and temperature not specified in the publication Rattus norvegicus stepharotudine
0.0413
-
pH and temperature not specified in the publication Rattus norvegicus tetrahydropalmatine
0.0425
-
pH and temperature not specified in the publication Rattus norvegicus oxoxylopine
0.05
-
IC50 above 0.05 mM, pH and temperature not specified in the publication Rattus norvegicus isocorydine
0.05
-
IC50 above 0.05 mM, pH and temperature not specified in the publication Rattus norvegicus thalifoline