Literature summary for 3.1.1.7 extracted from

Wong, K.K.; Ngo, J.C.; Liu, S.; Lin, H.Q.; Hu, C.; Shaw, P.C.; Wan, D.C.
Interaction study of two diterpenes, cryptotanshinone and dihydrotanshinone, to human acetylcholinesterase and butyrylcholinesterase by molecular docking and kinetic analysis (2010), Chem. Biol. Interact., 187, 335-339.

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Inhibitors

Inhibitors	Comment	Organism	Structure
cryptotanshinone	mixed non-competitive inhibitor	Homo sapiens
dihydrotanshinone	mixed non-competitive inhibitor	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P22303	-	-

Synonyms

Synonyms	Comment	Organism
AChE	-	Homo sapiens

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.00064	-	dihydrotanshinone	pH and temperature not specified in the publication	Homo sapiens
0.00673	-	cryptotanshinone	pH and temperature not specified in the publication	Homo sapiens

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.00089	-	pH and temperature not specified in the publication	Homo sapiens	dihydrotanshinone
0.00467	-	pH and temperature not specified in the publication	Homo sapiens	cryptotanshinone

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Release 2023.1 (January 2023)