Literature summary for 3.1.1.7 extracted from

Wille, T.; Ekstroem, F.; Lee, J.C.; Pang, Y.P.; Thiermann, H.; Worek, F.
Kinetic analysis of interactions between alkylene-linked bis-pyridiniumaldoximes and human acetylcholinesterases inhibited by various organophosphorus compounds (2010), Biochem. Pharmacol., 80, 941-946.

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Inhibitors

Inhibitors	Comment	Organism	Structure
1,1'-heptane-1,7-diylbis{2-[(E)-(hydroxyimino)methyl]pyridinium}	reversible inhibition, 0.000385 mM reduces the activity to 76%; reversible inhibition, reduces the activity to 89% and 44% at concentrations of 0.0000385 mM and 0.000385 mM, respectively	Homo sapiens
1,1'-nonane-1,9-diylbis{2-[(E)-(hydroxyimino)methyl]pyridinium}	reversible inhibition, enzyme activity is inhibited to 64% and 15% at 0.0000385 mM and 0.000385 mM, respectively	Homo sapiens
cyclosarin	-	Homo sapiens
paraoxon-ethyl	-	Homo sapiens
sarin	-	Homo sapiens
Tabun	-	Homo sapiens
VX (nerve agent)	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
erythrocyte	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
acetylcholine + H2O	-	Homo sapiens	choline + acetate	-	?

Synonyms

Synonyms	Comment	Organism
AChE	-	Homo sapiens

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Release 2023.1 (January 2023)