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Literature summary for 3.1.1.7 extracted from
- Effect of different buffers on kinetic properties of human acetylcholinesterase and the interaction with organophosphates and oximes (2011), Arch. Toxicol., 85, 193-198.
General Stability
| General Stability | Organism |
|---|---|
| compared to phosphate buffer, the inhibition and reactivation kinetics of human erythrocyte AChE are markedly changed by Tris and in part by MOPS, whereas Tyrode buffer shows similar results to phosphate buffer (0.1 M each) | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| paraoxon-ethyl | - |
Homo sapiens |  |
| sarin | - |
Homo sapiens | |
| soman | - |
Homo sapiens | |
| VX (nerve agent) | - |
Homo sapiens | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0714 | - |
Acetylcholine | in 0.1 M MOPS buffer (pH 7.4), at 37°C | Homo sapiens | |
| 0.0982 | - |
Acetylcholine | in 0.1 M phosphate buffer (pH 7.4), at 37°C | Homo sapiens | |
| 0.1 | - |
Acetylcholine | in 0.1 M Tyrode buffer (pH 7.4), at 37°C | Homo sapiens | |
| 0.1215 | - |
Acetylcholine | in 0.1 M Tris buffer (pH 7.4), at 37°C | Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| erythrocyte | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetylcholine + H2O | - |
Homo sapiens | choline + acetate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| AChE | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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