Literature summary for 3.1.1.7 extracted from

Lima, M.M.; Lopez, J.A.; David, J.M.; Silva, E.P.; Giulietti, A.M.; de Queiroz, L.P.; David, J.P.
Acetylcholinesterase activity of alkaloids from the leaves of Waltheria brachypetala (2008), Planta Med., 75, 335-337.

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Inhibitors

Inhibitors	Comment	Organism	Structure
8-methoxyflindersine	an alkaloid isolated from Waltheria brachypetala	Homo sapiens
N-methylwaltherione	an alkaloid isolated from Waltheria brachypetala	Homo sapiens
physostigmine	71.2% inhibition at 0.1 mg/ml	Homo sapiens
waltherine	an alkaloid isolated from Waltheria brachypetala, 51.4% inhibition at 0.1 mg/ml	Homo sapiens
waltherione-A	an alkaloid isolated from Waltheria brachypetala, Waltheria douradinha, Melochia chamaedrys, and Melochia odorata leaves	Homo sapiens
waltherione-B	an alkaloid isolated from Waltheria brachypetala	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
erythrocyte	-	Homo sapiens	-

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
additional information	-	-	Homo sapiens	additional information

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Release 2023.1 (January 2023)