Activating Compound | Comment | Organism | Structure |
---|---|---|---|
presenilin 1 | i.e. PS1, the transmembrane protein plays a critical role in the gamma-secretase processing of the amyloid precursor protein to generate the beta-amyloid peptide, which accumulates in plaques in the pathogenesis of Alzheimers disease. The PS1-A246E pathogenic mutation expressed in transgenic mice leads to decreased AChE activity and alteration of AChE glycosylation, accessibility to its peripheral binding site, and the peripheral binding site, which may reflect a shift in protein conformation and disturbed AChE maturation | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
semiquantitative PCR expression analysis, overview | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
additional information | subcellular co-localization of PS1 and AChE in cultured cells perinuclear rigion and co-expression patterns of PS1 and AChE in brain sections from controls and subjects with sporadic or familial Alzheimer's disease | Homo sapiens | - |
- |
perinuclear space | perinuclear region of the cytoplasm of cultured cells | Homo sapiens | - |
- |
plasma membrane | - |
Homo sapiens | 5886 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
glycoprotein | mutation of presenilin 1 affects the enzyme glycosylation | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | cerebral, frontal cortex, subcellular co-localization of PS1 and AChE in the perinuclear region of the cytoplasm of cultured cells, and co-expression patterns of PS1 and AChE in brain sections from controls and subjects with sporadic or familial Azlheimer's disease | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-acetylthiocholine iodide + H2O | detection with 5,5'-dithio-bis-2-nitrobenzoic acid, i.e. DTNB | Homo sapiens | acetate + thiocholine iodide | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AChE | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
22 | - |
assay at | Homo sapiens |