Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.1.1.7 extracted from

  • Darvesh, S.; Darvesh, K.V.; McDonald, R.S.; Mataija, D.; Walsh, R.; Mothana, S.; Lockridge, O.; Martin, E.
    Carbamates with differential mechanism of inhibition toward acetylcholinesterase and butyrylcholinesterase (2008), J. Med. Chem., 51, 4200-4212.
    View publication on PubMed
Search for more literature for 3.1.1.7

Inhibitors

Inhibitors Comment Organism Structure
1-naphthyl phenothiazine carbamate
-
 Homo sapiens
2-(1-piperidinyl)ethyl phenothiazine carbamate
-
 Homo sapiens
2-(1-pyrrolidinyl)ethyl phenothiazine carbamate
-
 Homo sapiens
2-(4-morpholino)ethyl phenothiazine carbamate
-
 Homo sapiens
2-(N,N-diethylamino)ethyl phenothiazine carbamate
-
 Homo sapiens
2-(N,N-dimethylamino)ethyl phenothiazine carbamate
-
 Homo sapiens
2-chlorophenyl phenothiazine carbamate
-
 Homo sapiens
2-methoxyphenyl phenothiazine carbamate
-
 Homo sapiens
2-methylphenyl phenothiazine carbamate
-
 Homo sapiens
2-naphthyl phenothiazine carbamate
-
 Homo sapiens
2-t-butylphenyl phenothiazine carbamate
-
 Homo sapiens
3-(N,N-diethylamino)propyl phenothiazine carbamate
-
 Homo sapiens
3-(N,N-dimethylamino) phenyl phenothiazine carbamate binding by residues F329 and Y332, structure, overview Homo sapiens
3-chlorophenyl phenothiazine carbamate
-
 Homo sapiens
3-methoxyphenyl phenothiazine carbamate
-
 Homo sapiens
3-methylphenyl phenothiazine carbamate
-
 Homo sapiens
4-biphenyl phenothiazine carbamate
-
 Homo sapiens
4-chlorophenyl phenothiazine carbamate
-
 Homo sapiens
4-methoxyphenyl phenothiazine carbamate
-
 Homo sapiens
4-methylphenyl phenothiazine carbamate
-
 Homo sapiens
4-t-butylphenyl phenothiazine carbamate
-
 Homo sapiens
butyl carbamate
-
 Homo sapiens
cyclopentyl phenothiazine carbamate
-
 Homo sapiens
donepezil
-
 Homo sapiens
ethyl carbamate
-
 Homo sapiens
galanthamine
-
 Homo sapiens
additional information inhibitor molecular mechanics calculations, general mechanism of pseudoirreversible cholinesterase inhibition by carbamates. Enzyme deactivation is initiated by nucleophilic attack of the catalytic triad serine oxygen on the carbonyl group of the carbamate, structure-activity relationships, overview Homo sapiens
phenyl phenothiazine carbamate
-
 Homo sapiens
propyl phenothiazine carbamate
-
 Homo sapiens
rivastigmine
-
 Homo sapiens
t-butyl phenothiazine carbamate
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens acetylcholinesterase is a serine hydrolase that catalyze the hydrolysis of acetylcholine, thus regulating cholinergic neurotransmission ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetylthiocholine + H2O detection using 5,5'-dithiobis(2-nitrobenzoic acid) Homo sapiens acetate + thiocholine
-
 ?
additional information acetylcholinesterase is a serine hydrolase that catalyze the hydrolysis of acetylcholine, thus regulating cholinergic neurotransmission Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
acetylcholinesterase
-
 Homo sapiens
AChE
-
 Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
additional information
-
 additional information molecular mechanics calculations and inhibition kinetics, overview Homo sapiens