Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.1.1.7 extracted from

  • Belluti, F.; Piazzi, L.; Bisi, A.; Gobbi, S.; Bartolini, M.; Cavalli, A.; Valenti, P.; Rampa, A.
    Design, synthesis, and evaluation of benzophenone derivatives as novel acetylcholinesterase inhibitors (2008), Eur. J. Med. Chem., 44, 1341-1348.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
(3,4-dimethoxyphenyl)-(4-([(2-dimethylaminoethyl)-methylamino]methyl)phenyl)-methanone
-
Homo sapiens
(3,4-dimethoxyphenyl)-(4-([(2-methoxybenzyl)methylamino]methyl)phenyl)-methanone
-
Homo sapiens
(3,4-dimethoxyphenyl)-(4-([methyl-(3-methylbenzyl)amino]methyl)phenyl)methanone
-
Homo sapiens
(3,4-dimethoxyphenyl)-(4-([methyl-(3-nitrobenzyl)amino]methyl)phenyl)methanone
-
Homo sapiens
(3,4-dimethoxyphenyl)-(4-morpholin-4-ylmethylphenyl)methanone
-
Homo sapiens
(3,4-dimethoxyphenyl)-(4-[(methylprop-2-ynylamino)-methyl]phenyl)methanone
-
Homo sapiens
(3,4-dimethoxyphenyl)-{4-[(ethylpropylamino)methyl]phenyl}methanone
-
Homo sapiens
(4-([benzyl-(2-dimethylaminoethyl)amino]methyl)-phenyl)-(3,4-dimethoxyphenyl)methanone
-
Homo sapiens
(4-([benzyl-(2-hydroxyethyl)amino]methyl)phenyl)-(3,4-dimethoxyphenyl)methanone
-
Homo sapiens
(4-[(benzylethylamino)methyl]phenyl)-(3,4-dimethoxyphenyl)methanone
-
Homo sapiens
(4-[(benzylmethylamino)methyl]phenyl)-(3,4-dimethoxyphenyl)methanone
-
Homo sapiens
(4-[(benzylmethylamino)methyl]phenyl)-(3-fluoro-4-methoxyphenyl)methanone
-
Homo sapiens
(4-[(benzylmethylamino)methyl]phenyl)-(4-methoxyphenyl)methanone
-
Homo sapiens
(4-[(benzylmethylamino)methyl]phenyl)naphthalen-2-yl-methanone
-
Homo sapiens
(4-[3-(benzylmethylamino)propenyl]phenyl)-(3,4-dimethoxyphenyl)methanone
-
Homo sapiens
donepezil
-
Homo sapiens
additional information design, synthesis, and evaluation of benzophenone derivatives as novel acetylcholinesterase inhibitors, structure-based drug design, overview Homo sapiens
[4-(3,4-dihydro-1H-isoquinolin-2-ylmethyl)phenyl]-(3,4-dimethoxyphenyl)methanone
-
Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
Homo sapiens
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
serum
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetylthiocholine iodide + H2O detection with 5,5'-dithio-bis-2-nitrobenzoic acid, i.e. DTNB Homo sapiens acetate + thiocholine iodide
-
?

Synonyms

Synonyms Comment Organism
AChE
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
assay at Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00002
-
-
Homo sapiens donepezil
0.00046
-
pH 8.0, 37°C Homo sapiens (4-[(benzylmethylamino)methyl]phenyl)-(3,4-dimethoxyphenyl)methanone
0.0006
-
pH 8.0, 37°C Homo sapiens (4-[(benzylethylamino)methyl]phenyl)-(3,4-dimethoxyphenyl)methanone
0.0014
-
pH 8.0, 37°C Homo sapiens (4-([benzyl-(2-hydroxyethyl)amino]methyl)phenyl)-(3,4-dimethoxyphenyl)methanone
0.0016
-
pH 8.0, 37°C Homo sapiens (4-[(benzylmethylamino)methyl]phenyl)-(3-fluoro-4-methoxyphenyl)methanone
0.0017
-
pH 8.0, 37°C Homo sapiens (3,4-dimethoxyphenyl)-(4-([methyl-(3-methylbenzyl)amino]methyl)phenyl)methanone
0.0018
-
pH 8.0, 37°C Homo sapiens (4-[(benzylmethylamino)methyl]phenyl)-(4-methoxyphenyl)methanone
0.0021
-
pH 8.0, 37°C Homo sapiens (4-[3-(benzylmethylamino)propenyl]phenyl)-(3,4-dimethoxyphenyl)methanone
0.0024
-
pH 8.0, 37°C Homo sapiens (3,4-dimethoxyphenyl)-(4-([(2-dimethylaminoethyl)-methylamino]methyl)phenyl)-methanone
0.0037
-
pH 8.0, 37°C Homo sapiens (3,4-dimethoxyphenyl)-(4-([(2-methoxybenzyl)methylamino]methyl)phenyl)-methanone
0.0043
-
pH 8.0, 37°C Homo sapiens (3,4-dimethoxyphenyl)-(4-([methyl-(3-nitrobenzyl)amino]methyl)phenyl)methanone
0.0086
-
pH 8.0, 37°C Homo sapiens (4-([benzyl-(2-dimethylaminoethyl)amino]methyl)-phenyl)-(3,4-dimethoxyphenyl)methanone
0.0196
-
pH 8.0, 37°C Homo sapiens (4-[(benzylmethylamino)methyl]phenyl)naphthalen-2-yl-methanone
0.0272
-
pH 8.0, 37°C Homo sapiens (3,4-dimethoxyphenyl)-(4-[(methylprop-2-ynylamino)-methyl]phenyl)methanone
0.0368
-
pH 8.0, 37°C Homo sapiens (3,4-dimethoxyphenyl)-(4-[(ethylpropylamino)methyl]phenyl)methanone
0.054
-
pH 8.0, 37°C Homo sapiens [4-(3,4-dihydro-1H-isoquinolin-2-ylmethyl)phenyl]-(3,4-dimethoxyphenyl)methanone
0.345
-
pH 8.0, 37°C Homo sapiens (3,4-dimethoxyphenyl)-(4-morpholin-4-ylmethylphenyl)methanone