Literature summary for 3.1.1.7 extracted from

Pavlov, V.A.; Parrish, W.R.; Rosas-Ballina, M.; Ochani, M.; Puerta, M.; Ochani, K.; Chavan, S.; Al-Abed, Y.; Tracey, K.J.
Brain acetylcholinesterase activity controls systemic cytokine levels through the cholinergic anti-inflammatory pathway (2009), Brain Behav. Immun., 23, 41-45.

Search for more literature for 3.1.1.7

Inhibitors

Inhibitors	Comment	Organism	Structure
galanthamine	a competitive and reversible, specific inhibitor, crosses the blood brain barrier, significantly increases brain cholinergic network activity	Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Mus musculus	brain acetylcholinesterase activity controls systemic cytokine levels through the cholinergic anti-inflammatory pathway, overview	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	male BALB/c mice, C57BL/6 mice with a7nAChR deficiency and wild-type littermates	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	-	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	brain acetylcholinesterase activity controls systemic cytokine levels through the cholinergic anti-inflammatory pathway, overview	Mus musculus	?	-	?

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Release 2023.1 (January 2023)