Literature summary for 3.1.1.7 extracted from

Berkov, S.; Codina, C.; Viladomat, F.; Bastida, J.
N-Alkylated galanthamine derivatives: potent acetylcholinesterase inhibitors from Leucojum aestivum (2008), Bioorg. Med. Chem. Lett., 18, 2263-2266.

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Inhibitors

Inhibitors	Comment	Organism	Structure
epinorgalanthamine	isolated from mother liquors/waste material obtained after industrial production of galanthamine hydrobromide from Leucojum aestivum leaves	Tetronarce californica
galanthamine	isolated from mother liquors/waste material obtained after industrial production of galanthamine hydrobromide from Leucojum aestivum leaves	Tetronarce californica
lycorine	isolated from mother liquors/waste material obtained after industrial production of galanthamine hydrobromide from Leucojum aestivum leaves	Tetronarce californica
additional information	inhibitor structural screening by GC-MS, binding structure, overview	Tetronarce californica
N-(14-methylallyl)norgalanthamine	isolated from mother liquors/waste material obtained after industrial production of galanthamine hydrobromide from Leucojum aestivum leaves, structure determination by NMR spectroscopy	Tetronarce californica
N-allylnorgalanthamine	isolated from mother liquors/waste material obtained after industrial production of galanthamine hydrobromide from Leucojum aestivum leaves, structure determination by NMR spectroscopy	Tetronarce californica
narwedine	isolated from mother liquors/waste material obtained after industrial production of galanthamine hydrobromide from Leucojum aestivum leaves	Tetronarce californica

Organism

Organism	UniProt	Comment	Textmining
Tetronarce californica	-	-	-

Synonyms

Synonyms	Comment	Organism
AChE	-	Tetronarce californica

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.00016	-	-	Tetronarce californica	N-(14-methylallyl)norgalanthamine
0.00018	-	-	Tetronarce californica	N-allylnorgalanthamine
0.00182	-	-	Tetronarce californica	galanthamine

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Release 2023.1 (January 2023)