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Literature summary for 3.1.1.7 extracted from

  • Zdrazilova, P.; Stepankova, S.; Komersova, A.; Vranova, M.; Komers, K.; Cegan, A.
    Kinetics of 13 new cholinesterase inhibitors (2006), Z. Naturforsch. C, 61, 611-617.
    View publication on PubMed
Search for more literature for 3.1.1.7

Inhibitors

Inhibitors Comment Organism Structure
2-chlorophenyl 1,2-dimethylhydrazinecarboxylate
-
 Bos taurus
2-chlorophenyl 1,2-dimethylhydrazinecarboxylate
-
 Electrophorus electricus
2-chlorophenyl 1-methylhydrazinecarboxylate
-
 Bos taurus
2-chlorophenyl 1-methylhydrazinecarboxylate
-
 Electrophorus electricus
3-chlorophenyl 1,2-dimethylhydrazinecarboxylate
-
 Bos taurus
3-chlorophenyl 1,2-dimethylhydrazinecarboxylate
-
 Electrophorus electricus
3-chlorophenyl 1-methylhydrazinecarboxylate
-
 Bos taurus
3-chlorophenyl 1-methylhydrazinecarboxylate
-
 Electrophorus electricus
3-N,N-diethylaminophenyl-N'-(1-alkyl) carbamates inhibit quickly by carbamoylation Bos taurus
3-N,N-diethylaminophenyl-N'-(1-alkyl) carbamates inhibit quickly by carbamoylation Electrophorus electricus
3-N,N-diethylaminophenyl-N'-(1-butyl) carbamate
-
 Bos taurus
3-N,N-diethylaminophenyl-N'-(1-butyl) carbamate
-
 Electrophorus electricus
3-N,N-diethylaminophenyl-N'-(1-ethyl) carbamate
-
 Bos taurus
3-N,N-diethylaminophenyl-N'-(1-ethyl) carbamate
-
 Electrophorus electricus
3-N,N-diethylaminophenyl-N'-(1-hexyl) carbamate
-
 Bos taurus
3-N,N-diethylaminophenyl-N'-(1-hexyl) carbamate
-
 Electrophorus electricus
3-N,N-diethylaminophenyl-N'-(1-octyl) carbamate
-
 Bos taurus
3-N,N-diethylaminophenyl-N'-(1-octyl) carbamate
-
 Electrophorus electricus
3-N,N-diethylaminophenyl-N'-(1-propyl) carbamate
-
 Bos taurus
3-N,N-diethylaminophenyl-N'-(1-propyl) carbamate
-
 Electrophorus electricus
4-chlorophenyl 1,2-dimethylhydrazinecarboxylate
-
 Bos taurus
4-chlorophenyl 1,2-dimethylhydrazinecarboxylate
-
 Electrophorus electricus
4-chlorophenyl 1-methylhydrazinecarboxylate
-
 Bos taurus
4-chlorophenyl 1-methylhydrazinecarboxylate
-
 Electrophorus electricus
additional information some inhibitors fullfill the competitive inhibition model with irreversible reaction between enzyme and inhibitor, but e.g. not galantamin Bos taurus
additional information some inhibitors fullfill the competitive inhibition model with irreversible reaction between enzyme and inhibitor, but e.g. not galantamin Electrophorus electricus
phenyl 1,2-dimethylhydrazinecarboxylate
-
 Bos taurus
phenyl 1,2-dimethylhydrazinecarboxylate
-
 Electrophorus electricus
phenyl 1-methylhydrazinecarboxylate
-
 Bos taurus
phenyl 1-methylhydrazinecarboxylate
-
 Electrophorus electricus
rivastigmin
-
 Bos taurus
rivastigmin
-
 Electrophorus electricus
sevin
-
 Bos taurus
sevin
-
 Electrophorus electricus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetylcholine + H2O Bos taurus
-
 choline + acetate
-
 ?
acetylcholine + H2O Electrophorus electricus
-
 choline + acetate
-
 ?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Electrophorus electricus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
erythrocyte
-
 Bos taurus
-
erythrocyte
-
 Electrophorus electricus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.5
-
-
 Bos taurus
3.5
-
-
 Electrophorus electricus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetylcholine + H2O
-
 Bos taurus choline + acetate
-
 ?
acetylcholine + H2O
-
 Electrophorus electricus choline + acetate
-
 ?
acetylthiocholine + H2O
-
 Bos taurus thiocholine + acetate
-
 ?
acetylthiocholine + H2O
-
 Electrophorus electricus thiocholine + acetate
-
 ?

Synonyms

Synonyms Comment Organism
AChE
-
 Bos taurus
AChE
-
 Electrophorus electricus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
 assay at Bos taurus
25
-
 assay at Electrophorus electricus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
 assay at Bos taurus
8
-
 assay at Electrophorus electricus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
additional information
-
 additional information inhibition kinetics, value of carbamoylation inhibition Bos taurus
additional information
-
 additional information inhibition kinetics, value of carbamoylation inhibition Electrophorus electricus