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Literature summary for 3.1.1.7 extracted from
- Brain regional acetylcholinesterase activity and muscarinic acetylcholine receptors in rats after repeated administration of cholinesterase inhibitors and its withdrawal (2007), Toxicol. Appl. Pharmacol., 219, 151-161.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| propoxur | - |
Rattus norvegicus |  |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| AF-DX 384 | - |
Rattus norvegicus | |
| dichlorvos | in vivo inhibition in the brain, overview | Rattus norvegicus | |
| additional information | no inhibition by oxotremorine, effects of inhibitors on muscarinic acetylcholine receptors, overview | Rattus norvegicus | |
| pirenzepine | - |
Rattus norvegicus | |
| quinuclidinyl benzilate | - |
Rattus norvegicus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetylcholine + H2O | Rattus norvegicus | - |
choline + acetate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
male Wistar rats | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Rattus norvegicus | - |
| cerebral cortex | - |
Rattus norvegicus | - |
| hippocampus | - |
Rattus norvegicus | - |
| striatum | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
brain tissue-specific activity, overview | Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetylcholine + H2O | - |
Rattus norvegicus | choline + acetate | - |
? | |
| acetylthiocholine + H2O | - |
Rattus norvegicus | thiocholine + acetate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| AChE | - |
Rattus norvegicus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 25 | - |
assay at | Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8 | - |
assay at | Rattus norvegicus |
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Release 2023.1 (January 2023)
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