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Literature summary for 3.1.1.7 extracted from
- Acetylcholinesterase in the sea urchin Lytechinus variegatus: Characterization and developmental expression in larvae (2008), Comp. Biochem. Physiol. B, 149, 401-409.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| BW284c51 | - |
Lytechinus variegatus |  |
| dichlorvos | irreversible inhibition | Lytechinus variegatus | |
| ethopropazine | - |
Lytechinus variegatus | |
| iso-ompa | very poor inhibitor | Lytechinus variegatus | |
| neostigmine | covalent, slow, and reversible inhibition | Lytechinus variegatus | |
| paraoxon | irreversible inhibition | Lytechinus variegatus | |
| physostigmine | covalent, slow, and reversible inhibition | Lytechinus variegatus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | kinetics | Lytechinus variegatus | |
| 0.036 | - |
butyrylthiocholine | - |
Lytechinus variegatus | |
| 0.308 | - |
acetylthiocholine | - |
Lytechinus variegatus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Lytechinus variegatus | - |
sea urchins collected from St. Joseph Bay, Florida in May of 2006 | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| larva | eight-arm F1 larvae | Lytechinus variegatus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetylthiocholine + H2O | - |
Lytechinus variegatus | thiocholine + acetate | - |
? | |
| butyrylthiocholine + H2O | - |
Lytechinus variegatus | thiocholine + butyrate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | the enzyme exists in both dimeric and tetrameric globular forms | Lytechinus variegatus |
| tetramer | the enzyme exists in both dimeric and tetrameric globular forms | Lytechinus variegatus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| AChE | - |
Lytechinus variegatus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 22 | - |
assay at room temperature | Lytechinus variegatus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7 | - |
assay at | Lytechinus variegatus |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | inhibition kinetcis | Lytechinus variegatus | |
| 0.000106 | - |
physostigmine | pH 7.0, 22°C | Lytechinus variegatus | |
| 0.000718 | - |
BW284c51 | pH 7.0, 22°C | Lytechinus variegatus | |
| 2.57 | - |
ethopropazine | pH 7.0, 22°C | Lytechinus variegatus | |
| 30 | - |
iso-ompa | pH 7.0, 22°C | Lytechinus variegatus | |
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