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Literature summary for 3.1.1.7 extracted from

  • Stojan, J.; Brochier, L.; Alies, C.; Colletier, J.P.; Fournier, D.
    Inhibition of Drosophila melanogaster acetylcholinesterase by high concentrations of substrate (2004), Eur. J. Biochem., 271, 1364-1371.
    View publication on PubMed
Search for more literature for 3.1.1.7

Protein Variants

Protein Variants Comment Organism
D375A more than 5% of wild-type activity, kinetics of substrate inhibition Drosophila melanogaster
D375G more than 5% of wild-type activity, kinetics of substrate inhibition Drosophila melanogaster
E237A more than 5% of wild-type activity, kinetics of substrate inhibition Drosophila melanogaster
E237G more than 5% of wild-type activity, kinetics of substrate inhibition Drosophila melanogaster
E237Q more than 5% of wild-type activity, kinetics of substrate inhibition Drosophila melanogaster
E69A more than 5% of wild-type activity, kinetics of substrate inhibition Drosophila melanogaster
E69I more than 5% of wild-type activity, kinetics of substrate inhibition Drosophila melanogaster
E69K more than 5% of wild-type activity, kinetics of substrate inhibition Drosophila melanogaster
E69L more than 5% of wild-type activity, kinetics of substrate inhibition Drosophila melanogaster
E69W more than 5% of wild-type activity, kinetics of substrate inhibition Drosophila melanogaster
E69Y more than 5% of wild-type activity, kinetics of substrate inhibition Drosophila melanogaster
F330A more than 5% of wild-type activity, kinetics of substrate inhibition Drosophila melanogaster
F330C more than 5% of wild-type activity, kinetics of substrate inhibition Drosophila melanogaster
F330G more than 5% of wild-type activity, kinetics of substrate inhibition Drosophila melanogaster
F330H more than 5% of wild-type activity, kinetics of substrate inhibition Drosophila melanogaster
F330I more than 5% of wild-type activity, kinetics of substrate inhibition Drosophila melanogaster
F330L more than 5% of wild-type activity, kinetics of substrate inhibition Drosophila melanogaster
F330S more than 5% of wild-type activity, kinetics of substrate inhibition Drosophila melanogaster
F330V more than 5% of wild-type activity, kinetics of substrate inhibition Drosophila melanogaster
F330W more than 5% of wild-type activity, kinetics of substrate inhibition Drosophila melanogaster
F330Y more than 5% of wild-type activity, kinetics of substrate inhibition Drosophila melanogaster
F371A more than 5% of wild-type activity, kinetics of substrate inhibition Drosophila melanogaster
F371G more than 5% of wild-type activity, kinetics of substrate inhibition Drosophila melanogaster
F371Y more than 5% of wild-type activity, kinetics of substrate inhibition Drosophila melanogaster
F77S more than 5% of wild-type activity, kinetics of substrate inhibition Drosophila melanogaster
G265A more than 5% of wild-type activity, kinetics of substrate inhibition Drosophila melanogaster
G368A more than 5% of wild-type activity, kinetics of substrate inhibition Drosophila melanogaster
I161K more than 5% of wild-type activity, kinetics of substrate inhibition Drosophila melanogaster
I161T more than 5% of wild-type activity, kinetics of substrate inhibition Drosophila melanogaster
L328A more than 5% of wild-type activity, kinetics of substrate inhibition Drosophila melanogaster
L328F more than 5% of wild-type activity, kinetics of substrate inhibition Drosophila melanogaster
M153A more than 5% of wild-type activity, kinetics of substrate inhibition Drosophila melanogaster
R70V more than 5% of wild-type activity, kinetics of substrate inhibition Drosophila melanogaster
V182L more than 5% of wild-type activity, kinetics of substrate inhibition Drosophila melanogaster
V318A more than 5% of wild-type activity, kinetics of substrate inhibition Drosophila melanogaster
V318D more than 5% of wild-type activity, kinetics of substrate inhibition Drosophila melanogaster
W271G more than 5% of wild-type activity, kinetics of substrate inhibition Drosophila melanogaster
W321A more than 5% of wild-type activity, kinetics of substrate inhibition Drosophila melanogaster
W321L more than 5% of wild-type activity, kinetics of substrate inhibition Drosophila melanogaster
W83A more than 5% of wild-type activity, kinetics of substrate inhibition Drosophila melanogaster
W83E more than 5% of wild-type activity, shift of inhibition towards higher substrate concentration Drosophila melanogaster
W83Y more than 5% of wild-type activity, kinetics of substrate inhibition Drosophila melanogaster
Y162A more than 5% of wild-type activity, kinetics of substrate inhibition Drosophila melanogaster
Y324A more than 5% of wild-type activity, kinetics of substrate inhibition Drosophila melanogaster
Y370A more than 5% of wild-type activity, kinetics of substrate inhibition Drosophila melanogaster
Y370C more than 5% of wild-type activity, shift of inhibition towards higher substrate concentration Drosophila melanogaster
Y370F more than 5% of wild-type activity, kinetics of substrate inhibition Drosophila melanogaster
Y370L more than 5% of wild-type activity, kinetics of substrate inhibition Drosophila melanogaster
Y370P more than 5% of wild-type activity, kinetics of substrate inhibition Drosophila melanogaster
Y370S more than 5% of wild-type activity, kinetics of substrate inhibition Drosophila melanogaster
Y374A more than 5% of wild-type activity, kinetics of substrate inhibition Drosophila melanogaster
Y71A more than 5% of wild-type activity, kinetics of substrate inhibition Drosophila melanogaster
Y71D more than 5% of wild-type activity, shift of inhibition towards higher substrate concentration Drosophila melanogaster
Y71K more than 5% of wild-type activity, kinetics of substrate inhibition Drosophila melanogaster
Y73A more than 5% of wild-type activity, kinetics of substrate inhibition Drosophila melanogaster
Y73Q more than 5% of wild-type activity, kinetics of substrate inhibition Drosophila melanogaster

Inhibitors

Inhibitors Comment Organism Structure
4-ketoamyl trimethyl ammonium iodide nonhydrolysable substrate analogue, mechanism of substrate inhibition Drosophila melanogaster
Acetylcholine mechanism of substrate inhibition Drosophila melanogaster

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster
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