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Literature summary for 3.1.1.7 extracted from

  • Kua, J.; Zhang, Y.; Eslami, A.C.; Butler, J.R.; McCammon, J.A.
    Studying the roles of W86, E202, and Y337 in binding of acetylcholine to acetylcholinesterase using a combined molecular dynamics and multiple docking approach (2003), Protein Sci., 12, 2675-2684.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.1.7

Cloned(Commentary)

Cloned (Comment) Organism
-
 Homo sapiens

Protein Variants

Protein Variants Comment Organism
E202A results in significant reduction in binding of extended acetylcholine in the catalytically productive orientation Homo sapiens
E202D results in significant reduction in binding of extended acetylcholine in the catalytically productive orientation Homo sapiens
E202Q results in significant reduction in binding of extended acetylcholine in the catalytically productive orientation Homo sapiens
W68A results in significant reduction in binding of extended acetylcholine in the catalytically productive orientation Homo sapiens
W68F results in significant reduction in binding of extended acetylcholine in the catalytically productive orientation Homo sapiens
Y337A results in significant reduction in binding of extended acetylcholine in the catalytically productive orientation Homo sapiens
Y337F results in significant reduction in binding of extended acetylcholine in the catalytically productive orientation Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.043
-
 acetylthiocholine E202Q mutant Homo sapiens
0.046
-
 acetylthiocholine wild-type enzyme Homo sapiens
0.053
-
 acetylthiocholine Y337F mutant Homo sapiens
0.11
-
 acetylthiocholine Y337A mutant Homo sapiens
0.276
-
 acetylthiocholine W68F mutant Homo sapiens
0.66
-
 acetylthiocholine E202D mutant Homo sapiens
30.64
-
 acetylthiocholine W68A mutant Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetylthiocholine + H2O
-
 Homo sapiens thiocholine + acetate
-
 ?