Cloned (Comment) | Organism |
---|---|
- |
Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
A262C | mutant retains hydrolytic activity | Mus musculus |
H287C | mutant retains hydrolytic activity | Mus musculus |
Y124C | mutant retains hydrolytic activity | Mus musculus |
Y124C-acrylodan | mutant retains hydrolytic activity | Mus musculus |
Y124C-benzyl | mutant retains hydrolytic activity | Mus musculus |
Y124C-N(CH3)3+ | mutant with increased Km | Mus musculus |
Y124C-NH3+ | mutant with increased Km | Mus musculus |
Y124C-SO3- | mutant retains hydrolytic activity | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
fasciculin | inhibits catalysis peripherally by sealing the mouth of the active center gorge | Mus musculus | |
trifluoroacetophenone | inhibits Y124C mutant slower than the wild-type enzyme | Mus musculus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.046 | - |
Acetylcholine | wild-type | Mus musculus | |
0.058 | - |
Acetylcholine | H287C mutant | Mus musculus | |
0.058 | - |
Acetylcholine | Y124C-SO3- mutant | Mus musculus | |
0.059 | - |
Acetylcholine | A262C mutant | Mus musculus | |
0.059 | - |
Acetylcholine | Y124C-benzyl mutant | Mus musculus | |
0.065 | - |
Acetylcholine | Y124C mutant | Mus musculus | |
0.28 | - |
Acetylcholine | Y124C-acrylodan mutant | Mus musculus | |
1.13 | - |
Acetylcholine | Y124C-N(Ch3)3+ mutant | Mus musculus | |
2.36 | - |
Acetylcholine | Y124C-NH3+ mutant | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetylcholine + H2O | Mus musculus | - |
choline + acetate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetylcholine + H2O | - |
Mus musculus | choline + acetate | - |
? |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
95 | - |
Acetylcholine | Y124C-acrylodan mutant | Mus musculus | |
1330 | - |
Acetylcholine | Y124C-benzyl mutant | Mus musculus | |
1333 | - |
Acetylcholine | Y124C-benzyl mutant | Mus musculus | |
1850 | - |
Acetylcholine | Y124C-N(Ch3)3+ mutant | Mus musculus | |
2130 | - |
Acetylcholine | Y124C-SO3- mutant | Mus musculus | |
2133 | - |
Acetylcholine | Y124C-SO3- mutant | Mus musculus | |
2330 | - |
Acetylcholine | wild-type | Mus musculus | |
2333 | - |
Acetylcholine | wild-type | Mus musculus | |
2367 | - |
Acetylcholine | Y124C mutant | Mus musculus | |
2370 | - |
Acetylcholine | Y124C mutant | Mus musculus | |
2730 | - |
Acetylcholine | A262C mutant | Mus musculus | |
2733 | - |
Acetylcholine | A262C mutant | Mus musculus | |
3000 | - |
Acetylcholine | H287C mutant | Mus musculus | |
4350 | - |
Acetylcholine | Y124C-NH3+ mutant | Mus musculus |