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Literature summary for 3.1.1.7 extracted from
- Characterization of acetylcholinesterase in Caco-2 cells (2002), Exp. Biol. Med., 227, 480-486.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 1,5-bis(4-allyldimethylammoniumphenyl)-pentan-3-one dibromide | i.e. BW284c51 | Homo sapiens |  |
| Echothiophate | 99% inhibition of detergent-soluble enzyme activity at 0.001 mM, does not inhibit the soluble enzyme | Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| plasma membrane | active site faces the external fluid | Homo sapiens | 5886 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| Caco-2 cell | well-differentiated colonic adenocarcinoma cell line | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetyl-beta-methylthiocholine + H2O | - |
Homo sapiens | beta-methylthiocholine + acetate | - |
? | |
| acetylthiocholine + H2O | best substrate | Homo sapiens | thiocholine + acetate | - |
? | |
| butyrylthiocholine + H2O | - |
Homo sapiens | thiocholine + butyrate | - |
? | |
| propionylthiocholine + H2O | - |
Homo sapiens | thiocholine + propionate | - |
? | |
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Release 2023.1 (January 2023)
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