Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.1.1.67 extracted from

  • Heith, A.M.; Morse, C.R.; Tsujita, T.; Volpacelli, S.A.; Flood, J.G.; Laposata, M.
    Fatty acid ethyl ester synthase catalyzes the esterification of ethanol to cocaine (1995), Biochem. Biophys. Res. Commun., 208, 549-554.
    View publication on PubMed
Search for more literature for 3.1.1.67

Application

Application Comment Organism
medicine enzyme is responsible for the formation of fatty acid ethyl esters, which are mediators of ethanol-induced organ damage Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cocaine + ethanol Homo sapiens enzyme may be responsible for a portion of cocaethylene synthesis in vivo cocaethylene + methanol product enhances cocaine toxicity ?
fatty acid + ethanol Homo sapiens enzyme is present selectively in the organs damaged by ethanol abuse fatty acyl ethyl ester + H2O responsible for the formation of FAEE, which are mediators of ethanol-induced organ damage ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
duodenum only FAEES activity, no cocaethylene synthase activity Homo sapiens
-
lung
-
 Homo sapiens
-
muscle
-
 Homo sapiens
-
spleen
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cocaine + ethanol
-
 Homo sapiens cocaethylene + methanol
-
 ?
cocaine + ethanol enzyme may be responsible for a portion of cocaethylene synthesis in vivo Homo sapiens cocaethylene + methanol product enhances cocaine toxicity ?
fatty acid + ethanol
-
 Homo sapiens fatty acyl ethyl ester + H2O
-
 ?
fatty acid + ethanol enzyme is present selectively in the organs damaged by ethanol abuse Homo sapiens fatty acyl ethyl ester + H2O responsible for the formation of FAEE, which are mediators of ethanol-induced organ damage ?
oleate + ethanol
-
 Homo sapiens ethyl oleate + H2O
-
 ?
p-nitrophenyl butyrate + H2O hydrolysis Homo sapiens butyrate + p-nitrophenol
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens