Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Colipase | stimulates hydrolysis of triglycerides, e.g. triolein | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
NaCl | inhibits hydrolysis of triglycerides, e.g. triolein | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Homo sapiens | 5829 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
50000 | 55000 | gel filtration | Homo sapiens |
52000 | - |
1 * 52000, SDS-PAGE | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
fatty acid + ethanol | Homo sapiens | important pathway for the metabolism of ingested ethanol, involved in the metabolism of fatty acids, triglycerides and ethanol | fatty acyl ethyl ester + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
1200fold | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
pancreas | - |
Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.04 | - |
pH 7.2, 37°C | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
arachidonate + ethanol | 16.7% of the rate with oleate or linoleate | Homo sapiens | ethyl arachidonate + H2O | - |
? | |
fatty acid + ethanol | - |
Homo sapiens | fatty acyl ethyl ester + H2O | - |
? | |
fatty acid + ethanol | important pathway for the metabolism of ingested ethanol, involved in the metabolism of fatty acids, triglycerides and ethanol | Homo sapiens | fatty acyl ethyl ester + H2O | - |
? | |
linoleate + ethanol | at the same rate as with oleate | Homo sapiens | ethyl linoleate + H2O | - |
? | |
additional information | enzyme has triglyceride lipase activity and also cleaves triglycerides, e.g. triolein, pancreatic fatty acid ethyl ester synthase and triglyceride lipase are likely the same enzymes | Homo sapiens | ? | - |
? | |
additional information | enzyme contains a specific heparin-binding site | Homo sapiens | ? | - |
? | |
oleate + ethanol | ethyl oleate synthesis to hydrolysis ratio of 80:1, at the same rate as with linoleate | Homo sapiens | ethyl oleate + H2O | - |
r | |
palmitate + ethanol | 12.5% of the rate with oleate or linoleate | Homo sapiens | ethyl palmitate + H2O | - |
? | |
stearate + ethanol | 4.2% of the rate with oleate or linoleate | Homo sapiens | ethyl stearate + H2O | - |
? | |
triolein + H2O | hydrolyzes triglycerides, e.g. triolein, 1.25% of the rate of ethyl oleate or ethyl linoleate synthesis | Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
monomer | 1 * 52000, SDS-PAGE | Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.2 | - |
assay at | Homo sapiens |