Literature summary for 3.1.1.55 extracted from

Hubbard, R.E.; OMahony, M.S.; Calver, B.L.; Woodhouse, K.W.
Plasma esterases and inflammation in ageing and frailty (2008), Eur. J. Clin. Pharmacol., 64, 895-900.

Search for more literature for 3.1.1.55

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	individuals with frailty (cognitive impairment) scores from 0.10 (young/healthy) up to 4.47	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
blood plasma	venous blood, similar aspirin esterase activity in frailty phenotype as in young/healthy phenotype	Homo sapiens	-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
additional information	-	125 nmol/min/ml plasma, day hospital patients: intermediate frailty phenotype (frailty score: 2.97), average age: 84.2 years	Homo sapiens
additional information	-	64 nmol/min/ml plasma, continuing, long-term care patients: frailty phenotype (frailty score: 4.47), average age: 84.9 years	Homo sapiens
additional information	-	82 nmol/min/ml plasma, young/healthy phenotype control (frailty score: 0.10), Caucasian, average age: 23.2 years	Homo sapiens
additional information	-	84 nmol/min/ml plasma, independent and age-matched controls (frailty score: 0.83), average age: 82.7 years	Homo sapiens

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
acetylsalicylic acid + H2O	20 min	Homo sapiens	salicylate + acetate	analysis and quantification of salicylate at 300 nm	?
additional information	no correlation between aspirin esterase activity and frailty phenotype, interleukin-6, tumour necrosis factor-alpha, or C-reactive protein	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
aspirin esterase	-	Homo sapiens
plasma aspirin esterase	-	Homo sapiens

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Release 2023.1 (January 2023)