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Literature summary for 3.1.1.55 extracted from

  • Kim, D.H.; Yang, Y.S.; Jakoby, W.B.
    Aspirin hydrolyzing esterases from rat liver cytosol (1990), Biochem. Pharmacol., 40, 481-487.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
bis-4-nitrophenyl phosphate
-
Rattus norvegicus
paraoxon complete inhibition at 0.1 mM Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00043
-
1-naphthyl acetate pH 7.8, 25°C, isozyme I Rattus norvegicus
0.00078
-
1-naphthyl acetate pH 7.8, 25°C, isozyme II Rattus norvegicus
0.0018
-
phenyl acetate pH 7.8, 25°C, isozyme I Rattus norvegicus
0.0026
-
phenyl acetate pH 7.8, 25°C, isozyme II Rattus norvegicus
0.0042
-
4-nitrophenyl acetate pH 7.8, 25°C, isozyme II Rattus norvegicus
0.0053
-
2-Nitrophenyl acetate pH 7.8, 25°C, isozyme I Rattus norvegicus
0.0059
-
Acetyl salicylate pH 7.8, 25°C, isozyme II Rattus norvegicus
0.0083
-
4-nitrophenyl acetate pH 7.8, 25°C, isozyme I Rattus norvegicus
0.0093
-
4-nitrophenyl butyrate pH 7.8, 25°C, isozyme I Rattus norvegicus
0.0098
-
2-Nitrophenyl acetate pH 7.8, 25°C, isozyme II Rattus norvegicus
0.017
-
2-Nitrophenyl butyrate pH 7.8, 25°C, isozyme II Rattus norvegicus
0.019
-
4-nitrophenyl butyrate pH 7.8, 25°C, isozyme II Rattus norvegicus
0.022
-
2-Nitrophenyl butyrate pH 7.8, 25°C, isozyme I Rattus norvegicus
0.098
-
4-acetoxybenzoate pH 7.8, 25°C, isozyme I Rattus norvegicus
0.11
-
4-acetoxybenzoate pH 7.8, 25°C, isozyme II Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Rattus norvegicus 5829
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
additional information
-
3 other cytoplasmic enzymes active with aspirin are observed differing in their MW of 220000 Rattus norvegicus
35000
-
isozyme I and II, gel filtration Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetyl salicylate + H2O Rattus norvegicus i.e. aspirin salicylate + acetate
-
?
acetyl salicylate + H2O Rattus norvegicus active in detoxification salicylate + acetate
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
2 isozymes I and II
-

Purification (Commentary)

Purification (Comment) Organism
isozymes arylesterase I and II, to homogeneity Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
Rattus norvegicus
1.2
-
purified isozyme I, substrate 4-nitrophenylacetate Rattus norvegicus
1.4
-
purified isozyme II, substrate 4-nitrophenylacetate Rattus norvegicus
2.5
-
purified isozyme I, substrate acetyl salicylate Rattus norvegicus
2.55
-
purified isozyme II, substrate acetyl salicylate Rattus norvegicus

Storage Stability

Storage Stability Organism
-20°C, pH 6.8, 7% loss of activity per month Rattus norvegicus
4°C, pH 6.8, 10% loss of activity per month Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-naphthyl acetate + H2O
-
Rattus norvegicus 1-naphthol + acetate
-
?
2-nitrophenyl acetate + H2O
-
Rattus norvegicus 2-nitrophenol + acetate
-
?
2-nitrophenyl butyrate + H2O
-
Rattus norvegicus 2-nitrophenol + butyrate
-
?
4-acetoxybenzoate + H2O
-
Rattus norvegicus 4-hydroxybenzoate + acetate
-
?
4-nitrophenyl acetate + H2O
-
Rattus norvegicus 4-nitrophenol + acetate
-
?
4-nitrophenyl butyrate + H2O
-
Rattus norvegicus 4-nitrophenol + butyrate
-
?
acetyl salicylate + H2O i.e. aspirin Rattus norvegicus salicylate + acetate
-
?
acetyl salicylate + H2O active in detoxification Rattus norvegicus salicylate + acetate
-
?
acetylsalicylate + H2O i.e. aspirin Rattus norvegicus salicylate + acetate
-
?
phenyl acetate + H2O
-
Rattus norvegicus phenol + acetate
-
?

Subunits

Subunits Comment Organism
monomer 1 * 35000, both isozymes, SDS-PAGE Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.8
-
-
Rattus norvegicus