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Literature summary for 3.1.1.53 extracted from

  • Chellappa, V.; Taylor, K.N.; Pedrick, K.; Donado, C.; Netravali, I.A.; Haider, K.; Cariappa, A.; Dalomba, N.F.; Pillai, S.
    M89V sialic acid acetyl esterase (SIAE) and all other non-synonymous common variants of this gene are catalytically normal (2013), PLoS ONE, 8, e53453.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.1.53

Cloned(Commentary)

Cloned (Comment) Organism
genotyping, exome sequencing, in HEK293 T cells overexpressed recombinant enzyme can be secreted by the transfected lymphocates, in the contrary to the physiological state of the enzyme Homo sapiens
genotyping, exome sequencing, in HEK293 T cells overexpressed recombinant enzyme can be secreted by the transfected lymphocytes, in the contrary to the physiological state of the enzyme Mus musculus

Protein Variants

Protein Variants Comment Organism
A385T naturally occuring mutation Homo sapiens
A394T naturally occuring mutation Homo sapiens
A467V naturally occuring mutation, the enzyme shows over 110% catalytic activity compared to the wild-type enzyme. The mutant is secreted upon overexpression Homo sapiens
C196F naturally occuring mutation, the mutant shows highly reduced catalytic activity compared with the wild-type enzyme Mus musculus
C443R naturally occuring mutation Homo sapiens
F404S naturally occuring mutation Homo sapiens
G419E naturally occuring mutation Homo sapiens
G514A naturally occuring mutation Homo sapiens
G64S naturally occuring mutation, the enzyme shows unaltered catalytic activity compared to the wild-type enzyme. The mutant enzyme is poorly secreted when overexpressed Homo sapiens
H447R naturally occuring mutation Homo sapiens
H472Q naturally occuring mutation Homo sapiens
K434T naturally occuring mutation Homo sapiens
K71R naturally occuring mutation, the enzyme shows over 50% catalytic activity compared to the wild-type enzyme. The mutant is secreted upon overexpression Homo sapiens
M456I naturally occuring mutation Homo sapiens
M456T naturally occuring mutation Homo sapiens
M89V naturally occuring mutation, the enzyme shows unaltered catalytic activity compared to the wild-type enzyme. The mutant enzyme is poorly secreted when overexpressed Homo sapiens
Q309P naturally occuring mutation, the mutant shows highly reduced catalytic activity compared with the wild-type enzyme Homo sapiens
Q335P naturally occuring mutation, the mutant shows highly reduced catalytic activity compared with the wild-type enzyme Mus musculus
Q428L naturally occuring mutation Homo sapiens
Q462R naturally occuring mutation Homo sapiens
R387W naturally occuring mutation Homo sapiens
R393C naturally occuring mutation Homo sapiens
R393H naturally occuring mutation Homo sapiens
R479C naturally occuring mutation Homo sapiens
S127A naturally occuring mutation, the enzyme shows below 10% catalytic activity compared to the wild-type enzyme Homo sapiens
V459I naturally occuring mutation Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
intracellular
-
 Mus musculus 5622
-
intracellular
-
 Homo sapiens 5622
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus sialic acid acetyl esterase removes acetyl moieties from the 9-OH position of sialic acid ?
-
 ?
additional information Homo sapiens sialic acid acetyl esterase removes acetyl moieties from the 9-OH position of sialic acid ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9HAT2
-
-
Mus musculus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information sialic acid acetyl esterase removes acetyl moieties from the 9-OH position of sialic acid Mus musculus ?
-
 ?
additional information sialic acid acetyl esterase removes acetyl moieties from the 9-OH position of sialic acid Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
SIAE
-
 Mus musculus
SIAE
-
 Homo sapiens
sialic acid acetyl esterase
-
 Mus musculus
sialic acid acetyl esterase
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function sialic acid acetyl esterase removes acetyl moieties from the 9-OH position of sialic acid, and thus permits alpha2,6 linked sialic acid on N-glycans on B cell glycoproteins to interact with CD22/Siglec-2, a sialic acid binding lectin that can inhibit B cell antigen receptor signaling Mus musculus
physiological function sialic acid acetyl esterase removes acetyl moieties from the 9-OH position of sialic acid, and thus permits alpha2,6 linked sialic acid on N-glycans on B cell glycoproteins to interact with CD22/Siglec-2, a sialic acid binding lectin that can inhibit B cell antigen receptor signaling Homo sapiens