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Literature summary for 3.1.1.53 extracted from

  • Mandal, C.; Mandal, C.; Chandra, S.; Schauer, R.; Mandal, C.
    Regulation of O-acetylation of sialic acids by sialate-O-acetyltransferase and sialate-O-acetylesterase activities in childhood acute lymphoblastic leukemia (2012), Glycobiology, 22, 70-83.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Homo sapiens 5829
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lysosome
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Homo sapiens 5764
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additional information multiple transcript variants of this gene encode different isoforms, found either in the lysosome or in the cytosol. The variant 1 represents the shorter transcript but encodes the longer protein, isoform 1, referred to as the lysosomal form of the protein. The variant 2 differs in the 5' UTR and coding region compared to transcript variant 1. The resulting protein, isoform 2, has a distinct N-terminus and is also referred as the cytosolic form of the protein Homo sapiens
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-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
B-lymphocyte
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Homo sapiens
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lymphoblast
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Homo sapiens
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T-lymphocyte
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Homo sapiens
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Synonyms

Synonyms Comment Organism
SIAE
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Homo sapiens
sialate-O-acetylesterase
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Homo sapiens

Expression

Organism Comment Expression
Homo sapiens expression of lysosomal and cytosolic form of SIAE is significantly downregulated both in lymphoblasts of acute lymphoblastic leukemia patients and acute lymphoblastic leukemia-cell line in comparison to peripheral blood mononuclear cells from healthy donors, semi-quantitative RT-PCR using specific primers for both SIAE genes, overview down

General Information

General Information Comment Organism
malfunction decreased sialate-O-acetylesterase activity occurs both in lysosomal and cytosolic fractions of childhood acute lymphoblastic leukemia, ALL, cell lines and primary cells from bone marrow of patients compared to peripheral blood mononuclear cells from healthy donors, which preferentially hydrolyse O-acetyl groups at C-9 of Sia Homo sapiens
physiological function sialate-O-acetylesterases, SIAE, are important enzymes in sialic acid metabolism. They hydrolyse 4- or 9-O-acetyl groups of either glycosidically linked or free sialic acids released from glycoconjugates by sialidases. Both sialate-O-acetylesterase, SIAE, and sialate-O-acetyltranferase, SOAT, activities seem to be responsible for the enhanced level of Neu5,9Ac2 in lymphoblasts, which is a hall mark in acute lymphoblastic leukemia Homo sapiens