Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Homo sapiens | 5829 | - |
lysosome | - |
Homo sapiens | 5764 | - |
additional information | multiple transcript variants of this gene encode different isoforms, found either in the lysosome or in the cytosol. The variant 1 represents the shorter transcript but encodes the longer protein, isoform 1, referred to as the lysosomal form of the protein. The variant 2 differs in the 5' UTR and coding region compared to transcript variant 1. The resulting protein, isoform 2, has a distinct N-terminus and is also referred as the cytosolic form of the protein | Homo sapiens | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
B-lymphocyte | - |
Homo sapiens | - |
lymphoblast | - |
Homo sapiens | - |
T-lymphocyte | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
SIAE | - |
Homo sapiens |
sialate-O-acetylesterase | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | expression of lysosomal and cytosolic form of SIAE is significantly downregulated both in lymphoblasts of acute lymphoblastic leukemia patients and acute lymphoblastic leukemia-cell line in comparison to peripheral blood mononuclear cells from healthy donors, semi-quantitative RT-PCR using specific primers for both SIAE genes, overview | down |
General Information | Comment | Organism |
---|---|---|
malfunction | decreased sialate-O-acetylesterase activity occurs both in lysosomal and cytosolic fractions of childhood acute lymphoblastic leukemia, ALL, cell lines and primary cells from bone marrow of patients compared to peripheral blood mononuclear cells from healthy donors, which preferentially hydrolyse O-acetyl groups at C-9 of Sia | Homo sapiens |
physiological function | sialate-O-acetylesterases, SIAE, are important enzymes in sialic acid metabolism. They hydrolyse 4- or 9-O-acetyl groups of either glycosidically linked or free sialic acids released from glycoconjugates by sialidases. Both sialate-O-acetylesterase, SIAE, and sialate-O-acetyltranferase, SOAT, activities seem to be responsible for the enhanced level of Neu5,9Ac2 in lymphoblasts, which is a hall mark in acute lymphoblastic leukemia | Homo sapiens |