Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3,4-dichloroisocoumarin | - |
bovine coronavirus | |
3,4-dichloroisocoumarin | - |
influenza C virus | |
3,4-dichloroisocoumarin | - |
Murine hepatitis virus | |
3,4-dichloroisocoumarin | - |
Rat sialodacryoadenitis coronavirus | |
ammonium (allyl 5-acetamido-3,5-dideoxy-4-O-methyl-D-glycero-alpha-D-galacto-2-nonulopyranosidonate) | - |
Murine hepatitis virus | |
ammonium (allyl 5-acetamido-3,5-dideoxy-4-O-methyl-D-glycero-alpha-D-galacto-2-nonulopyranosidonate) | - |
Rat sialodacryoadenitis coronavirus | |
ammonium (allyl 5-acetamido-9-O-methyl-3,5-dideoxy-D-glycero-alpha-D-galacto-2-nonulopyranosidonate) | - |
bovine coronavirus | |
ammonium (allyl 5-acetamido-9-O-methyl-3,5-dideoxy-D-glycero-alpha-D-galacto-2-nonulopyranosidonate) | - |
influenza C virus | |
diammonium (allyl 5-acetamido-3,5-dideoxy-4-O-(P-methylphosphonyl)-D-glycero-alpha-D-galacto-2-nonulopyranosidonate) | - |
Murine hepatitis virus | |
diammonium (allyl 5-acetamido-3,5-dideoxy-4-O-(P-methylphosphonyl)-D-glycero-alpha-D-galacto-2-nonulopyranosidonate) | - |
Rat sialodacryoadenitis coronavirus | |
diammonium (allyl 5-acetamido-3,5-dideoxy-9-O-(P-methylphosphonyl)-D-glycero-alpha-D-galacto-2-nonulopyranosidonate) | - |
bovine coronavirus | |
diammonium (allyl 5-acetamido-3,5-dideoxy-9-O-(P-methylphosphonyl)-D-glycero-alpha-D-galacto-2-nonulopyranosidonate) | - |
influenza C virus | |
additional information | synthesis and evaluation of a series of sialosides modified at the 4- and 9-hydroxy group for inhibition of the viral haemagglutinin-esterase activity from various Orthomyxoviruses and Coronaviruses, overview. While no inhibition of the sialate-4-O-acetylesterases from Mouse hepatitis virus strain S or Sialodacryoadenitis virus is found, a 9-O-methyl derivative displays inhibitory activity against recombinant sialate-9-O-acetylesterase from Influenza C virus. No inhibition of Bovine coronavirus by ammonium (allyl 5-acetamido-3,5-dideoxy-4-O-methyl-D-glycero-alpha-D-galacto-2-nonulopyranosidonate) and diammonium (allyl 5-acetamido-3,5-dideoxy-4-O-(P-methylphosphonyl)-D-glycero-alpha-D-galacto-2-nonulopyranosidonate) | bovine coronavirus | |
additional information | synthesis and evaluation of a series of sialosides modified at the 4- and 9-hydroxy group for inhibition of the viral haemagglutinin-esterase activity from various Orthomyxoviruses and Coronaviruses, overview. While no inhibition of the sialate-4-O-acetylesterases from Mouse hepatitis virus strain S or Sialodacryoadenitis virus is found, a 9-O-methyl derivative displays inhibitory activity against recombinant sialate-9-Oacetylesterase from Influenza C virus. No inhibition of Influenza C virus by ammonium (allyl 5-acetamido-3,5-dideoxy-4-O-methyl-D-glycero-a-D-galacto-2-nonulopyranosidonate) and diammonium (allyl 5-acetamido-3,5-dideoxy-4-O-(P-methylphosphonyl)-D-glycero-a-d-galacto-2-nonulopyranosidonate) | influenza C virus | |
additional information | synthesis and evaluation of a series of sialosides modified at the 4- and 9-hydroxy group for inhibition of the viral haemagglutinin-esterase activity from various Orthomyxoviruses and Coronaviruses, overview. While no inhibition of the sialate-4-O-acetylesterases from Mouse hepatitis virus strain S or Sialodacryoadenitis virus is found, a 9-O-methyl derivative displays inhibitory activity against recombinant sialate-9-O-acetylesterase from Influenza C virus. No inhibition of Mouse hepatitis virus strain S by ammonium (allyl 5-acetamido-9-O-methyl-3,5-dideoxy-D-glycero-alpha-D-galacto-2-nonulopyranosidonate) and diammonium (allyl 5-acetamido-3,5-dideoxy-9-O-(P-methylphosphonyl)-D-glycero-alpha-D-galacto-2-nonulopyranosidonate) | Murine hepatitis virus | |
additional information | synthesis and evaluation of a series of sialosides modified at the 4- and 9-hydroxy group for inhibition of the viral haemagglutinin-esterase activity from various Orthomyxoviruses and Coronaviruses, overview. While no inhibition of the sialate-4-O-acetylesterases from Mouse hepatitis virus strain S or Sialodacryoadenitis virus is found, a 9-O-methyl derivative displays inhibitory activity against recombinant sialate-9-O-acetylesterase from Influenza C virus. No inhibition of Rat sialoadacryoadenitis coronavirus by ammonium (allyl 5-acetamido-9-O-methyl-3,5-dideoxy-dglycero-alpha-D-galacto-2-nonulopyranosidonate) and diammonium (allyl 5-acetamido-3,5-dideoxy-9-O-(P-methylphosphonyl)-D-glycero-alpha-D-galacto-2-nonulopyranosidonate) | Rat sialodacryoadenitis coronavirus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | bovine coronavirus | the enzyme of Bovine coronavirus exhibits sialate-9-O-acetylesterase specificity | ? | - |
? | |
additional information | influenza C virus | the enzyme of Influenza C virus exhibits sialate-9-O-acetylesterase specificity | ? | - |
? | |
additional information | Murine hepatitis virus | the enzyme of Influenzy C virus exhibits sialate-4-O-acetylesterase specificity | ? | - |
? | |
additional information | Rat sialodacryoadenitis coronavirus | the enzyme of Rat sialoadacryoadenitis coronavirus exhibits sialate-4-O-acetylesterase specificity | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
bovine coronavirus | - |
BcoV | - |
influenza C virus | - |
- |
- |
Murine hepatitis virus | - |
- |
- |
Rat sialodacryoadenitis coronavirus | - |
SDAV | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-nitrophenyl acetate + H2O | - |
influenza C virus | 4-nitrophenol + acetate | - |
? | |
4-nitrophenyl acetate + H2O | - |
Murine hepatitis virus | 4-nitrophenol + acetate | - |
? | |
4-nitrophenyl acetate + H2O | - |
bovine coronavirus | 4-nitrophenol + acetate | - |
? | |
4-nitrophenyl acetate + H2O | - |
Rat sialodacryoadenitis coronavirus | 4-nitrophenol + acetate | - |
? | |
additional information | the enzyme of Bovine coronavirus exhibits sialate-9-O-acetylesterase specificity | bovine coronavirus | ? | - |
? | |
additional information | the enzyme of Influenza C virus exhibits sialate-9-O-acetylesterase specificity | influenza C virus | ? | - |
? | |
additional information | the enzyme of Influenzy C virus exhibits sialate-4-O-acetylesterase specificity | Murine hepatitis virus | ? | - |
? | |
additional information | the enzyme of Rat sialoadacryoadenitis coronavirus exhibits sialate-4-O-acetylesterase specificity | Rat sialodacryoadenitis coronavirus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
4-SOAE | - |
influenza C virus |
4-SOAE | - |
Murine hepatitis virus |
4-SOAE | - |
bovine coronavirus |
4-SOAE | - |
Rat sialodacryoadenitis coronavirus |
9-SOAE | - |
influenza C virus |
9-SOAE | - |
Murine hepatitis virus |
9-SOAE | - |
bovine coronavirus |
9-SOAE | - |
Rat sialodacryoadenitis coronavirus |
sialate-4-O-acetylesterase | - |
influenza C virus |
sialate-4-O-acetylesterase | - |
Murine hepatitis virus |
sialate-4-O-acetylesterase | - |
bovine coronavirus |
sialate-4-O-acetylesterase | - |
Rat sialodacryoadenitis coronavirus |
sialate-9-O-acetylesterase | - |
influenza C virus |
sialate-9-O-acetylesterase | - |
Murine hepatitis virus |
sialate-9-O-acetylesterase | - |
bovine coronavirus |
sialate-9-O-acetylesterase | - |
Rat sialodacryoadenitis coronavirus |
sialate-O-acetylesterase | - |
influenza C virus |
sialate-O-acetylesterase | - |
Murine hepatitis virus |
sialate-O-acetylesterase | - |
bovine coronavirus |
sialate-O-acetylesterase | - |
Rat sialodacryoadenitis coronavirus |
SOAE | - |
influenza C virus |
SOAE | - |
Murine hepatitis virus |
SOAE | - |
bovine coronavirus |
SOAE | - |
Rat sialodacryoadenitis coronavirus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
22 | - |
assay at room temperature | influenza C virus |
22 | - |
assay at room temperature | Murine hepatitis virus |
22 | - |
assay at room temperature | bovine coronavirus |
22 | - |
assay at room temperature | Rat sialodacryoadenitis coronavirus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | influenza C virus |
7.4 | - |
assay at | Murine hepatitis virus |
7.4 | - |
assay at | bovine coronavirus |
7.4 | - |
assay at | Rat sialodacryoadenitis coronavirus |
General Information | Comment | Organism |
---|---|---|
physiological function | besides sialidases, the haemagglutinin-esterases of Influenza C virus, Isavirus, Betacoronaviruses and Toroviruses represent another class of receptor-destroying enzymes, RDEs. They are sialate-O-acetylesterases, SOAE, hydrolysing O-acetyl esters of O-acetylated sialic acid derivatives as sialate-4-O-acetylesterases, 4-SOAE, and sialate-9-O-acetylesterases, 9-SOAE. The enzyme of Bovine coronavirus exhibits sialate-9-O-acetylesterase specificity | bovine coronavirus |
physiological function | besides sialidases, the haemagglutinin-esterases of Influenza C virus, Isavirus, Betacoronaviruses and Toroviruses represent another class of receptor-destroying enzymes, RDEs. They are sialate-O-acetylesterases, SOAE, hydrolysing O-acetyl esters of O-acetylated sialic acid derivatives as sialate-4-O-acetylesterases, 4-SOAE, and sialate-9-O-acetylesterases, 9-SOAE. The enzyme of Influenza C virus exhibits sialate-9-O-acetylesterase specificity | influenza C virus |
physiological function | besides sialidases, the haemagglutinin-esterases of Influenza C virus, Isavirus, Betacoronaviruses and Toroviruses represent another class of receptor-destroying enzymes, RDEs. They are sialate-O-acetylesterases, SOAE, hydrolysing O-acetyl esters of O-acetylated sialic acid derivatives as sialate-4-O-acetylesterases, 4-SOAE, and sialate-9-O-acetylesterases, 9-SOAE. The enzyme of Mouse hepatitis virus strain S exhibits sialate-4-O-acetylesterase specificity | Murine hepatitis virus |
physiological function | besides sialidases, the haemagglutinin-esterases of Influenza C virus, Isavirus, Betacoronaviruses and Toroviruses represent another class of receptor-destroying enzymes, RDEs. They are sialate-O-acetylesterases, SOAE, hydrolysing O-acetyl esters of O-acetylated sialic acid derivatives as sialate-4-O-acetylesterases, 4-SOAE, and sialate-9-O-acetylesterases, 9-SOAE. The enzyme of Rat sialoadacryoadenitis coronavirus exhibits sialate-4-O-acetylesterase specificity | Rat sialodacryoadenitis coronavirus |