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Literature summary for 3.1.1.53 extracted from
- Recombinant viral sialate-O-acetylesterases (2004), Glycoconj. J., 20, 551-561.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed as GFP-fused secretion protein in Sf9 cells | influenza C virus |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| S57T | loss of esterase activity | influenza C virus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| diisopropyl fluorophosphate | DFP strong inhibition | influenza C virus |  |
| additional information | no inhibition by PMSF | influenza C virus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | - |
influenza C virus | 16020 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| N-acetyl-O-acetylneuraminate + H2O | influenza C virus | destroys receptors on the surface of the target cells | N-acetylneuraminate + acetate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| influenza C virus | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| glycoprotein | - |
influenza C virus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 9-O-acetyl sialic acid + H2O | - |
influenza C virus | sialic acid + acetate | - |
? | |
| bovine submaxillary mucin + H2O | - |
influenza C virus | ? | - |
? | |
| additional information | incubation of the enzyme with chicken erythrocytes abolishes the agglutinability the erythrocytes | influenza C virus | ? | - |
? | |
| N-acetyl-O-acetylneuraminate + H2O | destroys receptors on the surface of the target cells | influenza C virus | N-acetylneuraminate + acetate | - |
? | |
| p-nitrophenyl acetate + H2O | - |
influenza C virus | p-nitrophenol + acetate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | two forms with molecular weights of 75000 and 88000 Da detected in SDS-PAGE, the 75000 Da form is assumed to by the unglycosylated precursor of the enzyme | influenza C virus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| HE | - |
influenza C virus |
| hemagglutinin-esterase | - |
influenza C virus |
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Release 2023.1 (January 2023)
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