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Literature summary for 3.1.1.5 extracted from

  • Satou, M.; Nishi, Y.; Yoh, J.; Hattori, Y.; Sugimoto, H.
    Identification and characterization of acyl-protein thioesterase 1/lysophospholipase I as a ghrelin deacylation/lysophospholipid hydrolyzing enzyme in fetal bovine serum and conditioned medium (2010), Endocrinology, 151, 4765-4775.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3) cells Homo sapiens
expressed in Escherichia coli BL21(DE3) cells Rattus norvegicus

Protein Variants

Protein Variants Comment Organism
D174A inactive Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Homo sapiens 5829
-
cytosol
-
Rattus norvegicus 5829
-
cytosol
-
Bos taurus 5829
-

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Homo sapiens
-
-
-
Mus musculus Q9WTL7
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Hep-G2 cell
-
Homo sapiens
-
RAW-264.7 cell isoform lysophospholipase I only Mus musculus
-
serum
-
Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-lysophosphatidylcholine + H2O
-
Homo sapiens glycerophosphocholine + a carboxylate
-
?
2-lysophosphatidylcholine + H2O
-
Rattus norvegicus glycerophosphocholine + a carboxylate
-
?
2-lysophosphatidylcholine + H2O
-
Bos taurus glycerophosphocholine + a carboxylate
-
?

Synonyms

Synonyms Comment Organism
acyl-protein thioesterase 1 exhibits deacylation activity as well as lysophospholipase activity in vitro Homo sapiens
acyl-protein thioesterase 1 exhibits deacylation activity as well as lysophospholipase activity in vitro Rattus norvegicus
acyl-protein thioesterase 1 exhibits deacylation activity as well as lysophospholipase activity in vitro Bos taurus
APT1 APT1 exhibits deacylation activity as well as lysophospholipase activity in vitro Homo sapiens
APT1 APT1 exhibits deacylation activity as well as lysophospholipase activity in vitro Rattus norvegicus
APT1 APT1 exhibits deacylation activity as well as lysophospholipase activity in vitro Bos taurus
lysophospholipase I isoform Homo sapiens
lysophospholipase I isoform Rattus norvegicus
lysophospholipase I isoform Bos taurus
lysophospholipase II isoform Homo sapiens
lysophospholipase II isoform Rattus norvegicus
lysophospholipase II isoform Bos taurus

Expression

Organism Comment Expression
Homo sapiens lipopolysaccharide suppresses APT1 mRNA and protein expression down
Rattus norvegicus lipopolysaccharide suppresses APT1 mRNA and protein expression down
Bos taurus lipopolysaccharide suppresses APT1 mRNA and protein expression down
Mus musculus APT1 is released at high levels from RAW264.7 macrophage-like cells into the culture medium after stimulation with lipopolysaccharide, the mRNA level of lysophospholipase II in RAW264.7 cells is much less than APT1 and not changed by lipopolysaccharide treatment up

General Information

General Information Comment Organism
physiological function the serum activity of APT1 plays an important role in determination of the concentration of des-acyl ghrelin in circulation, especially under septic inflammation Bos taurus