Application | Comment | Organism |
---|---|---|
medicine | the gene for the beta subunit of brain enzyme isoform I is identical to a causative gene for Miller-Dieker lissencephaly | Bos taurus |
Cloned (Comment) | Organism |
---|---|
brain isoform I, expression of alpha1 and alpha2 subunits in Escherichia coli, expression of the beta subunit in Sf9 cells | Bos taurus |
Protein Variants | Comment | Organism |
---|---|---|
H149R | brain isoform I, beta subunit, mutant has no ability to associate with the catalytic alpha-complexes | Bos taurus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Bos taurus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O | i.e. PAF | Bos taurus | 1-O-alkyl-sn-glycero-3-phosphocholine + acetate | - |
? | |
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O | preferred substrate for alpha2/alpha2 homodimer of brain isoform I | Bos taurus | 1-O-alkyl-sn-glycero-3-phosphocholine + acetate | - |
? | |
1-O-alkyl-2-acetyl-sn-glycero-3-phosphoric acid + H2O | preferred substrate for the alpha1/alpha1 homodimer and the alpha1/alpha2 heterodimer | Bos taurus | 1-O-alkyl-sn-glycero-3-phosphoric acid + acetate | - |
? |
Subunits | Comment | Organism |
---|---|---|
trimer | the enzyme consists of two catalytic subunits alpha1 and alpha2 which form a catalytic dimer and a non-catalytic subunit beta. In addition the enzyme can aggregate to homodimers consisting of alpha1/alpha1 or alpha2/alpha2. The three forms differ in substrate specificity. The beta subunit accelerates the activity of the alpha2/alpha2 homodimer, suppresses the activity of the alpha1/alpha1 homodimer and has little influence on the activity of the alpha1/alpha2 heterodimer | Bos taurus |