Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.1.1.47 extracted from

  • Tsaoussis, V.; Vakirtzi-Lemonias, C.
    The mouse plasma PAF acetylhydrolase: I. Characterization and properties (1994), J. Lipid Mediat. Cell Signal., 9, 301-315.
    View publication on PubMed
Search for more literature for 3.1.1.47

Activating Compound

Activating Compound Comment Organism Structure
deoxycholate activation Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
1-O-hexadecyl-2-acetyl-rac-glycerol
-
 Mus musculus
1-O-hexadecyl-2-N-methylcarbamoyl-sn-glycero-3-phospho(N,N,N-trimethyl)hexanolamine
-
 Mus musculus
1-O-hexadecyl-2-N-methylcarbamoyl-sn-glycero-3-phosphocholine
-
 Mus musculus
1-O-hexadecyl-2-O-methyl-sn-glycero-3-phosphocholine
-
 Mus musculus
1-O-hexadecyl-2-thioacetyl-sn-glycero-3-phosphocholine
-
 Mus musculus
1-oleyl-2-acetyl-sn-glycerol
-
 Mus musculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0074
-
 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine
-
 Mus musculus

Metals/Ions

Metals/Ions Comment Organism Structure
additional information no stimulation by Ca2+ or Mg2+ Mus musculus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
46000
-
 x * 46000 + x * 63000, SDS-PAGE Mus musculus
63000
-
 x * 46000 + x * 63000, SDS-PAGE Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O Mus musculus the substrate is a potent lipid mediator, involved in pathological responses, particularly in inflammation and allergy. Its level is regulated by hydrolysis ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
plasma
-
 Mus musculus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.038
-
-
 Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O i.e. PAF Mus musculus 1-O-alkyl-sn-glycero-3-phosphocholine + acetate
-
 ?
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O the substrate is a potent lipid mediator, involved in pathological responses, particularly in inflammation and allergy. Its level is regulated by hydrolysis Mus musculus ?
-
 ?
1-O-hexadecyl-2-N-methylcarbamoyl-sn-glycero-3-phospho(N,N,N-trimethyl)hexanolamine
-
 Mus musculus ?
-
 ?

Subunits

Subunits Comment Organism
? x * 46000 + x * 63000, SDS-PAGE Mus musculus