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Literature summary for 3.1.1.47 extracted from

  • Howard, K.M.; Abdel-Al, M.; Ditmyer, M.; Patel, N.
    Lipopolysaccharide and platelet-activating factor stimulate expression of platelet-activating factor acetylhydrolase via distinct signaling pathways (2011), Inflamm. Res., 60, 735-744.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
expression of a fragment, corresponding to nucleotides 599-1123 of the human PAF-AH cDNA, quantitative realtime RT-PCR expression analysis in MM6 cells Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1-O-hexadecyl-2-O-acetyl-sn-glycero-3-phosphocholine + H2O Homo sapiens
-
 1-O-hexadecyl-sn-glycero-3-phosphocholine + acetate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Mono-Mac-6 cell MM6 cell Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-O-hexadecyl-2-O-acetyl-sn-glycero-3-phosphocholine + H2O
-
 Homo sapiens 1-O-hexadecyl-sn-glycero-3-phosphocholine + acetate
-
 ?

Synonyms

Synonyms Comment Organism
PAF-AH
-
 Homo sapiens
platelet-activating factor acetylhydrolase
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens no effect by lyso-PAF on PAF-AH expression additional information
Homo sapiens lipopolysaccharide and PAF strongly upregulate PAF-AH expression, the stimulation is susceptible to partial inhibition by p38 MAPK inhibitor SB-2033580 and PAF receptor antagonists WEB 2170 and BN50739, inhibition of the ERK1/2 portion of the MAPK pathway with PD98059 consistently increases PAF-AH expression relative to administration of lipopolysaccharide alone, overview. PAF-induced up-regulation of PAF-AH levels is solely mediated via the PAF receptor and is p38 MAPK-independent, lipopolysaccharide induce expression of the PAF receptor by 6-8fold up