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Literature summary for 3.1.1.47 extracted from

  • Liu, J.; Chen, R.; Marathe, G.K.; Febbraio, M.; Zou, W.; McIntyre, T.M.
    Circulating platelet-activating factor is primarily cleared by transport, not intravascular hydrolysis by lipoprotein-associated phospholipase A2/PAF acetylhydrolase (2011), Circ. Res., 108, 469-477.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.1.47

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular secreted plasma PAF acetylhydrolase Mus musculus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3-O-hexadecyl-2-acetyl-sn-glycero-1-phosphocholine + H2O Mus musculus
-
 3-O-hexadecyl-sn-glycero-1-phosphocholine + acetate
-
 ?
3-O-hexadecyl-2-acetyl-sn-glycero-1-phosphocholine + H2O Mus musculus BL6
-
 3-O-hexadecyl-sn-glycero-1-phosphocholine + acetate
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-
Mus musculus BL6
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
plasma
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3-O-hexadecyl-2-acetyl-sn-glycero-1-phosphocholine + H2O
-
 Mus musculus 3-O-hexadecyl-sn-glycero-1-phosphocholine + acetate
-
 ?
3-O-hexadecyl-2-acetyl-sn-glycero-1-phosphocholine + H2O
-
 Mus musculus BL6 3-O-hexadecyl-sn-glycero-1-phosphocholine + acetate
-
 ?

Synonyms

Synonyms Comment Organism
PAF acetylhydrolase
-
 Mus musculus
PAF-AH
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 Mus musculus
plasma PAF acetylhydrolase
-
 Mus musculus

General Information

General Information Comment Organism
metabolism reducing the role for circulating, although perhaps not intracellular, PLA2G7 in in vivo PAF catabolism. In vivo PAF clearance is independent of the PAF receptor Mus musculus
physiological function PAF is cleared from murine circulation in seconds as an intact molecule through saturable uptake by endothelium. This disappearance is faster than PAF hydrolysis in human or murine blood, and ablation of PLA2G7 has no immediate effect on PAF clearance Mus musculus