Literature summary for 3.1.1.47 extracted from

MacRitchie, A.N.; Gardner, A.A.; Prescott, S.M.; Stafforini, D.M.
Molecular basis for susceptibility of plasma platelet-activating factor acetylhydrolase to oxidative inactivation (2007), FASEB J., 21, 1164-1176.

Cloned(Commentary)

Cloned (Comment)	Organism
expression in Escherichia coli BL-21	Homo sapiens
expression in Escherichia coli BL-21	Mus musculus

Protein Variants

Protein Variants	Comment	Organism
additional information	the murine form of PAF-AH is more resistant to inactivation than the human ortholog: studies on chimeric constructs	Homo sapiens
additional information	the murine form of PAF-AH is more resistant to inactivation than the human ortholog: studies on chimeric constructs	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-
Mus musculus	A0JNU3 and Q61206 and Q61205	lysophospholipase and subunit beta and subunit gamma	-

Oxidation Stability

Oxidation Stability	Organism
catalytic activity of PAF-AH is sensitive to oxidants. Peroxynitrite mediates oxidative inactivation of PAF-AH. M117, and to a smaller contribution Y307 and Y335 are targets of oxidant attack. M117 is adjacent to W115 and L116, which are essential for association of PAF-AH with low-density lipoproteins. Oxidation of low-density lipoprotein-associated PAF-AH partially dissociates the enzyme from the particles. Oxidation of the purified enzyme in the absence of lipoproteins prevents subsequent association with low-density lipoproteins	Homo sapiens
catalytic activity of PAF-AH is sensitive to oxidants. Peroxynitrite mediates oxidative inactivation of PAF-AH. M117, and to a smaller contribution Y307 and Y335 are targets of oxidant attack. Oxidation of the purified enzyme in the absence of lipoproteins prevents subsequent association with low-density lipoproteins	Mus musculus

Organism

catalytic activity of PAF-AH is sensitive to oxidants. Peroxynitrite mediates oxidative inactivation of PAF-AH. M117, and to a smaller contribution Y307 and Y335 are targets of oxidant attack. M117 is adjacent to W115 and L116, which are essential for association of PAF-AH with low-density lipoproteins. Oxidation of low-density lipoprotein-associated PAF-AH partially dissociates the enzyme from the particles. Oxidation of the purified enzyme in the absence of lipoproteins prevents subsequent association with low-density lipoproteins

Homo sapiens

catalytic activity of PAF-AH is sensitive to oxidants. Peroxynitrite mediates oxidative inactivation of PAF-AH. M117, and to a smaller contribution Y307 and Y335 are targets of oxidant attack. Oxidation of the purified enzyme in the absence of lipoproteins prevents subsequent association with low-density lipoproteins

Mus musculus

Purification (Commentary)

Purification (Comment)	Organism
-	Homo sapiens
-	Mus musculus

Synonyms

Synonyms	Comment	Organism
PAF-AH	-	Homo sapiens
PAF-AH	-	Mus musculus