Cloned (Comment) | Organism |
---|---|
cloning of paf-1 gene homologue, expression in Escherichia coli | Caenorhabditis elegans |
cloning of paf-2 gene homologue, expression in Escherichia coli | Caenorhabditis elegans |
Protein Variants | Comment | Organism |
---|---|---|
additional information | loss of function mutants of the two homologous PAF-AH (II) genes, mutant organisms show defects in epithelial sheet formation, resulting in unsuccessful subsequent morphogenesis with complete penetrance | Caenorhabditis elegans |
additional information | loss of function mutants of the two homologous PAF-AH (II) genes, mutant organisms show defects in epithelial sheet formation, resulting in unsuccessful subsequent morphogenesis with complete penetrance, disruption of paf-2 results in severe impairment of embryonic development, embryos are found to be arrested in the bean stage and fail to elongate | Caenorhabditis elegans |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Caenorhabditis elegans | 5829 | - |
membrane | - |
Caenorhabditis elegans | 16020 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O | Caenorhabditis elegans | regulation of platelet-activating factor, essential for epithelial morphogenesis | 1-O-alkyl-sn-glycero-3-phosphocholine + acetate | - |
? | |
additional information | Caenorhabditis elegans | hydrolyzes also propionyl and butyloyl groups from phosphoglycerides, and truncated acyl chains derived from oxidative cleavage of long-chain polyunsaturated fatty acyl groups, suggesting that they have a role in scavenging selectively oxidized phospholipid species without acting on structural membrane phospholipids | ? | - |
? | |
additional information | Caenorhabditis elegans | hydrolyzes also propionyl and butyryl groups from phosphoglycerides, and truncated acyl chains derived from oxidative cleavage of long-chain polyunsaturated fatty acyl groups, suggesting that they have a role in scavenging selectively oxidized phospholipid species without acting on structural membrane phospholipids | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Caenorhabditis elegans | - |
product of the paf-1 gene homologue; Bristol strain N2, two homologous PAF-AH (II) genes, named paf-1 and paf-2 | - |
Caenorhabditis elegans | Q22943 | product of the paf-2 gene homologue; Bristol strain N2, two homologous PAF-AH (II) genes, named paf-1 and paf-2 | - |
Posttranslational Modification | Comment | Organism |
---|---|---|
additional information | N-myristoylated at the N-terminus | Caenorhabditis elegans |
Purification (Comment) | Organism |
---|---|
recombinant protein | Caenorhabditis elegans |
Source Tissue | Comment | Organism | Textmining |
---|
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O | - |
Caenorhabditis elegans | 1-O-alkyl-sn-glycero-3-phosphocholine + acetate | - |
? | |
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O | regulation of platelet-activating factor, essential for epithelial morphogenesis | Caenorhabditis elegans | 1-O-alkyl-sn-glycero-3-phosphocholine + acetate | - |
? | |
additional information | hydrolyzes also propionyl and butyloyl groups from phosphoglycerides, and truncated acyl chains derived from oxidative cleavage of long-chain polyunsaturated fatty acyl groups, suggesting that they have a role in scavenging selectively oxidized phospholipid species without acting on structural membrane phospholipids | Caenorhabditis elegans | ? | - |
? | |
additional information | hydrolyzes also propionyl and butyryl groups from phosphoglycerides, and truncated acyl chains derived from oxidative cleavage of long-chain polyunsaturated fatty acyl groups, suggesting that they have a role in scavenging selectively oxidized phospholipid species without acting on structural membrane phospholipids | Caenorhabditis elegans | ? | - |
? | |
additional information | no hydrolysis of long acyl chains attached to phosphatidylcholine | Caenorhabditis elegans | ? | - |
? | |
oxidized phosphatidylcholine + H2O | - |
Caenorhabditis elegans | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PAF-AH (II) | - |
Caenorhabditis elegans |
Type II platelet-activating factor-acetylhydrolase | - |
Caenorhabditis elegans |